Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Journal Article · Fri Jun 30 04:00:00 EDT 2006 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2006.04.121· OSTI ID:20854324

Sung, Hoon Ki ^[1]; Morisada, Tohru ^[2]; Cho, Chung-Hyun ^[1]; Oike, Yuichi ^[2]; Lee, Jayhun ^[1]; Sung, Eon Ki ^[3]; Chung, Jae Hoon ^[1]; Suda, Toshio ^[2]; Koh, Gou Young ^[1]

---

1. Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Korea, Republic of)
2. Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University Internal Medicine, Tokyo 160-8562 (Japan)
3. Department of Anatomy, Yeung Nam University Medical School, Daegu 705-717 (Korea, Republic of)

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

• OSTI ID: 20854324
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 345; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
BLOOD VESSELS
METASTASES
NEOPLASMS
RADIATION INJURIES
RADIOTHERAPY
SMALL INTESTINE