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Title: Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET

Abstract

Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [{sup 18}F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% (p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% (p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant (p = 0.02) and the mid/last implants (p = 0.008). The dose to 2 cm{sup 3} and 5 cm{sup 3} of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planningmore » allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.« less

Authors:
 [1];  [1];  [1];  [2];  [1];  [1];  [3];  [4];  [3];  [5]
  1. Radiation Oncology Department, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
  2. Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
  3. (United States)
  4. Division of Nuclear Medicine, Mallinckrodt Institute of RadiologySt. Louis, MO (United States)
  5. Radiation Oncology Department, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States). E-mail: pgrigsby@wustl.edu
Publication Date:
OSTI Identifier:
20850299
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.017; PII: S0360-3016(06)02733-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLADDER; BRACHYTHERAPY; CARCINOMAS; FLUORINE 18; GLUCOSE; OPTIMIZATION; PATIENTS; PLANNING; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIATION SOURCE IMPLANTS; RECTUM

Citation Formats

Lin, Lilie L., Mutic, Sasa, Low, Daniel A., La Forest, Richard, Vicic, Milos, Zoberi, Imran, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, Miller, Tom R., Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, and Grigsby, Perry W. Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.08.017.
Lin, Lilie L., Mutic, Sasa, Low, Daniel A., La Forest, Richard, Vicic, Milos, Zoberi, Imran, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, Miller, Tom R., Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, & Grigsby, Perry W. Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET. United States. doi:10.1016/j.ijrobp.2006.08.017.
Lin, Lilie L., Mutic, Sasa, Low, Daniel A., La Forest, Richard, Vicic, Milos, Zoberi, Imran, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, Miller, Tom R., Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, and Grigsby, Perry W. Mon . "Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET". United States. doi:10.1016/j.ijrobp.2006.08.017.
@article{osti_20850299,
title = {Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET},
author = {Lin, Lilie L. and Mutic, Sasa and Low, Daniel A. and La Forest, Richard and Vicic, Milos and Zoberi, Imran and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO and Miller, Tom R. and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO and Grigsby, Perry W.},
abstractNote = {Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [{sup 18}F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% (p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% (p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant (p = 0.02) and the mid/last implants (p = 0.008). The dose to 2 cm{sup 3} and 5 cm{sup 3} of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.},
doi = {10.1016/j.ijrobp.2006.08.017},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}