Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET
- Radiation Oncology Department, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
- Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
- Division of Nuclear Medicine, Mallinckrodt Institute of RadiologySt. Louis, MO (United States)
- Radiation Oncology Department, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States)
Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [{sup 18}F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% (p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% (p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant (p = 0.02) and the mid/last implants (p = 0.008). The dose to 2 cm{sup 3} and 5 cm{sup 3} of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.
- OSTI ID:
- 20850299
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 67, Issue 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.017; PII: S0360-3016(06)02733-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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