Three-dimensional conformal radiotherapy for locally advanced (Stage II and worse) head-and-neck cancer: Dosimetric and clinical evaluation

Journal Article · Wed Nov 15 04:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.03.014· OSTI ID:20850218

Portaluri, Maurizio ^[1]; Fucilli, Fulvio I.M. ^[2]; Castagna, Roberta ^[3]; Bambace, Santa ^[3]; Pili, Giorgio ^[2]; Tramacere, Francesco ^[3]; Russo, Donatella ^[3]; Francavilla, Maria Carmen ^[3]

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1. Department of Radiotherapy, AUSL Br-1, 'Di Summa-Perrino' Hospital, Brindisi (Italy) and National Research Council, IFC, Lecce (Italy)
2. Department of Medical Physics, AUSL Br-1, 'Di Summa-Perrino' Hospital, Brindisi (Italy)
3. Department of Radiotherapy, AUSL Br-1, 'Di Summa-Perrino' Hospital, Brindisi (Italy)

Purpose: To evaluate the dosimetric parameters of three-dimensional conformal radiotherapy (3D-CRT) in locally advanced head-and-neck tumors (Stage II and above) and the effects on xerostomia. Methods and Materials: A total of 49 patients with histologically proven squamous cell cancer of the head and neck were consecutively treated with 3D-CRT using a one-point setup technique; 17 had larynx cancer, 12 oropharynx, 12 oral cavity, and 6 nasopharynx cancer; 2 had other sites of cancer. Of the 49 patients, 41 received postoperative RT and 8 definitive treatment. Also, 13 were treated with cisplatin-based chemotherapy before and during RT; in 6 cases, 5-fluorouracil was added. The follow-up time was 484-567 days (median, 530 days). Results: One-point setup can deliver 96% of the prescribed dose to the isocenter, to the whole planning target volume, including all node levels of the neck and without overdosages. The mean dose to the primary planning target volume was 49.54 {+-} 4.82 Gy (51.53 {+-} 5.47 Gy for larynx cases). The average dose to the contralateral parotid gland was approximately 38 Gy (30 Gy for larynx cases). The maximal dose to the spinal cord was 46 Gy. A Grade 0 Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer xerostomia score corresponded to a mean dose of 30 Gy to one parotid gland. A lower xerostomia score with a lower mean parotid dose and longer follow-up seemed to give rise to a sort of functional recovery phenomenon. Conclusion: Three dimensional-CRT in head-and-neck cancers permits good coverage of the planning target volume with about 10-11 segments and one isocenter. With a mean dose of approximately 30 Gy to the contralateral parotid, we observed no or mild xerostomia.

• OSTI ID: 20850218
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 66; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CHEMOTHERAPY
EVALUATION
GLANDS
HEAD
LARYNX
NECK
ORAL CAVITY
PATIENTS
PHARYNX
PLANNING
RADIATION DOSES
RADIOTHERAPY
SPINAL CORD
URACILS