Prospective study on stereotactic radiotherapy of limited-stage non-small-cell lung cancer

Journal Article · Wed Nov 15 04:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.01.012· OSTI ID:20850205

Hoyer, Morten ^[1]; Roed, Henrik D ^[2]; Hansen, Anders Traberg ^[3]; Ohlhuis, Lars ^[2]; Petersen, Jorgen ^[3]; Nellemann, Hanne ^[4]; Berthelsen, Anne Kiil ^[2]; Grau, Cai D ^[1]; Engelholm, Svend Aage D ^[2]; Maase, Hans D. von der ^[1]

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1. Department of Oncology, Aarhus University Hospital, Aarhus (Denmark)
2. Department of Radiation Oncology, Copenhagen University Hospital, Copenhagen (Denmark)
3. Department of Medical Physics, Aarhus University Hospital, Aarhus (Denmark)
4. Department of Radiology, Aarhus University Hospital, Aarhus (Denmark)

Purpose: To test the effect of stereotactic body radiotherapy (SBRT) in the treatment of medically inoperable patients with limited-stage non-small-cell lung cancer (NSCLC) in a Phase II trial. Methods and Materials: Forty patients with Stage I NSCLC were treated with SBRT with a central dose of 15 Gy x 3 within 5-8 days. Results: Eight patients (20%) obtained a complete response, 15 (38%) had a partial response, and 12 (30%) had no change or could not be evaluated. Only 3 patients had a local recurrence, and the local control rate 2 years after SBRT was 85%. At 2 years, 54% were without local or distant progression, and overall survival was 47%. Within 6 months after treatment, one or more Grade {>=}2 reactions were observed in 48% of the patients. Conclusions: Stereotactic body radiotherapy in patients with limited-stage NSCLC resulted in a high probability of local control and a promising survival rate. The toxicity after SBRT of lung tumors was moderate. However, deterioration in performance status, respiratory insufficiency, and other side effects were observed.

• OSTI ID: 20850205
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 66; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
LUNGS
PATIENTS
PERFORMANCE
RADIATION DOSES
RADIOTHERAPY
SIDE EFFECTS
TOXICITY