Five-year survivors of brain metastases: A single-institution report of 32 patients

Journal Article · Tue Oct 31 23:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.05.015· OSTI ID:20850165

Chao, Samuel T ^[1]; Barnett, Gene H ^[1]; Liu, Stephanie W ^[2]; Reuther, Alwyn M ^[1]; Toms, Steven A ^[3]; Vogelbaum, Michael A ^[3]; Videtic, Gregory ^[1]; Suh, John H ^[1]

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1. Department of Radiation Oncology Brain Tumor Institute, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH (United States)
2. Feinberg School of Medicine, Northwestern University, Chicago, IL (United States)
3. Department of Neurosurgery, Brain Tumor Institute, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH (United States)

Purpose: To report on 32 patients who survived {>=}5 years from brain metastases treated at a single institution. Methods and Materials: The records of 1288 patients diagnosed with brain metastases between 1973 and 1999 were reviewed. Patients were treated with whole-brain radiation therapy (WBRT), surgery, and/or stereotactic radiosurgery (SRS). Thirty-two (2.5%) {>=}5-year survivors were identified. Factors contributing to long-term survival were identified. Results: Median survival was 9.3 years for {>=}5-year survivors. Seven of these patients lived {>=}10 years. Female gender was the only patient characteristic that correlated with better survival (p = 0.0369). When these patients were compared with <5-year survivors, age <65 years (p = 0.0044), control of the primary at diagnosis (p = 0.0052), no systemic disease (p = 0.0012), recursive partitioning analysis (RPA) Class 1 (p = 0.0002 with Class 2; p = 0.0022 with Class 3), and single brain metastasis (p = 0.0018) were associated with long-term survival in the univariate logistic regression model. In the multivariate model, RPA Class 1 compared with Class 2 (OR = 0.39, p = 0.0196), surgery (OR = 0.16, p < 0.0001), and SRS (OR = 0.41, p = 0.0188) were associated with long-term survival. Conclusions: For patients with good prognostic factors such as young age, good RPA characteristics and single metastasis, treatment with surgery or SRS offers the best chance for long-term survival.

• OSTI ID: 20850165
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 66; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
DIAGNOSIS
METASTASES
MULTIVARIATE ANALYSIS
PATIENTS
RADIOTHERAPY
SURGERY