ReVOLT: radiation-enhanced viral oncolytic therapy

Journal Article · Wed Nov 01 00:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.06.034· OSTI ID:20850144

Advani, Sunil J ^[1]; Mezhir, James J ^[2]; Roizman, Bernard ^[3]; Weichselbaum, Ralph R ^[1]

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1. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL (United States)
2. Department of Surgery, University of Chicago, Chicago, IL (United States)
3. Marjorie B. Kovler Viral Oncology Laboratories, University of Chicago, Chicago, IL (United States)

Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.

• OSTI ID: 20850144
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 66, Issue 3; Conference: 48. annual meeting of the American Society for Therapeutic Radiology and Oncology, Pennsylvania, PA (United States), 5-9 Nov 2006; Other Information: DOI: 10.1016/j.ijrobp.2006.06.034; PII: S0360-3016(06)01111-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOGENESIS
CLINICAL TRIALS
IONIZING RADIATIONS
MUTANTS
NEOPLASMS
RADIOTHERAPY
TUMOR CELLS
VIRUSES