Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: Analysis of 74 cases. A Rare Cancer Network study
- Department of Radiation Oncology, University of Piemonte Orientale, Novara (Italy)
- Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen (Netherlands)
- Department of Radiation Oncology, Centre G. F. Leclerc, Dijon (France)
- Department of Radiation Oncology, Dr. Bernard Verbeeten Instituut, Tilburg (Netherlands)
- Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)
- Department of Radiation Oncology, Hacettepe University Medical School, Ankara (Turkey)
- Department of Radiation Oncology, Institut Jules Bordet, Bruxelles (Belgium)
- Department of Radiation Oncology, Ospedale Oncologico A. Businco, Cagliari (Italy)
- Department of Radiation Oncology, Centre Hospitalier Universitaire de Besancon, Besancon (France)
Purpose: To retrospectively analyze a series of mucosal melanoma of the upper aerodigestive tract to determine the prognostic factors and contribute to understanding the role of radiotherapy in the therapeutic strategy. Methods and Materials: Seventy-four patients were analyzed. The most frequent locations were nasal and oral, in 31 patients (41.9%) and 12 patients (16.2%), respectively. Sixty-three patients (85.1%) were in Stage I, 5 (6.8%) in Stage II, and 6 (8.1%) in Stage III. Treatment consisted of surgery in 17 patients (23.0%), surgery and radiotherapy in 42 (56.8%), radiotherapy in 11 (14.9%), and chemo-immunotherapy in 4 (5.4%). Median follow-up was 20 months. Results: Local control at 3 years was 57% after surgery alone and 71% after surgery and radiotherapy. Overall and disease-free survival rates, respectively, were 41% and 31% at 3 years and 14% and 22% at 10 years. After univariate analysis, female gender, melanosis, tumor size {<=}3 cm, Stage I, postoperative radiotherapy, and complete remission were favorable prognostic factors. Stage I and melanosis were confirmed by multivariate analysis. Conclusions: Local control was improved by postoperative radiotherapy, despite survival being as poor as in other published series. Stage I and melanosis at diagnosis were the most favorable prognostic factors.
- OSTI ID:
- 20842906
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 65, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2006.01.016; PII: S0360-3016(06)00123-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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