Evaluation of two tomotherapy-based techniques for the delivery of whole-breast intensity-modulated radiation therapy

Journal Article · Mon May 01 04:00:00 EDT 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.1· OSTI ID:20793485

Gonzalez, Victor J ^[1]; Buchholz, Daniel J ^[2]; Langen, Katja M ^[2]; Olivera, Gustavo H ^[3]; Chauhan, Bhavin ^[2]; Meeks, Sanford L ^[2]; Ruchala, Kenneth J ^[3]; Haimerl, Jason ^[3]; Weiguo, Lu ^[3]; Kupelian, Patrick A ^[2]

---

1. Florida State University College of Medicine, Tallahassee, FL (United States)
2. Department of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, FL (United States)
3. TomoTherapy Inc., Madison, WI (United States)

Purpose: To evaluate two different techniques for whole-breast treatments delivered using the Hi-ART II tomotherapy device. Methods and Materials: Tomotherapy uses the standard rotational helical delivery. Topotherapy uses a stationary gantry while delivering intensity-modulated treatments. CT scans from 5 breast cancer patients were used. The prescription dose was 50.4 Gy. Results: On average, 99% of the target volume received 95% of prescribed dose with either technique. If treatment times are restricted to less than 9 min, the average percentage ipsilateral lung receiving {>=}20 Gy was 22% for tomotherapy vs. 10% for topotherapy. The ipsilateral lung receiving {>=}50.4 Gy was 4 cc for tomotherapy vs. 27 cc for topotherapy. The percentage of left ventricle receiving {>=}30 Gy was 14% with tomotherapy vs. 4% for topotherapy. The average doses to the contralateral breast and lung were 0.6 and 0.8 Gy, respectively, for tomotherapy vs. 0.4 and 0.3 Gy for topotherapy. Conclusions: Tomotherapy provides improved target dose homogeneity and conformality over topotherapy. If delivery times are restricted, topotherapy reduces the amount of heart and ipsilateral lung volumes receiving low doses. For whole-breast treatments, topotherapy is an efficient technique that achieves adequate target uniformity while maintaining low doses to sensitive structures.

• OSTI ID: 20793485
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 65; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
EVALUATION
HEART
LUNGS
MAMMARY GLANDS
PATIENTS
PLANNING
RADIATION DOSES
RADIOTHERAPY