FDG-PET imaging for the assessment of physiologic volume response during radiotherapy in cervix cancer

Journal Article · Mon May 01 04:00:00 EDT 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.1· OSTI ID:20793472

Lin, Lilie L ^[1]; Zhiyun, Yang ^[2]; Mutic, Sasa ^[1]; Miller, Tom R ^[2]; Grigsby, Perry W ^[3]

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1. Department of Radiation Oncology, Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
2. Division of Nuclear Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)
3. Department of Radiation Oncology, Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Division of Nuclear Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, MO (United States) and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (United States)

Purpose: To evaluate the physiologic tumor volume response during treatment in cervical cancer using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Patients and Methods: This was a prospective study of 32 patients. Physiologic tumor volume in cubic centimeters was determined from the FDG-PET images using the 40% threshold method. Results: The mean pretreatment tumor volume was 102 cm{sup 3}. The mean volume by clinical Stages I, II, and III were 54, 79, and 176 cm{sup 3}, respectively. After 19.8 Gy external irradiation to the pelvis, the reduction in tumor volume was 29% (72 cm{sup 3}). An additional 13 Gy from high-dose-rate (HDR) brachytherapy reduced the mean volume to 15.4 cm{sup 3}, and this was subsequently reduced to 8.6 cm{sup 3} with 13 Gy additional HDR brachytherapy (26 Gy, HDR). Four patients had physiologic FDG uptake in the cervix at 3 months after the completion of therapy. The mean time to the 50% reduction in physiologic tumor volume was 19.9 days and after combined external irradiation and HDR to 24.9 Gy. Conclusion: These results indicate that physiologic tumor volume determination by FDG-PET is feasible and that a 50% physiologic tumor volume reduction occurs within 20 days of starting therapy.

• OSTI ID: 20793472
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 65; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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