Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery

Journal Article · Sat Apr 01 04:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.1· OSTI ID:20793415

Massager, Nicolas ^[1]; Nissim, Ouzi ^[1]; Delbrouck, Carine ^[2]; Devriendt, Daniel ^[1]; David, Philippe ^[1]; Desmedt, Francoise ^[1]; Wikler, David ^[1]; Hassid, Sergio ^[2]; Brotchi, Jacques ^[1]; Levivier, Marc ^[1]

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1. Gamma Knife Center, Erasme Hospital, Universite Libre de Brixelles, Brussels (Belgium)
2. Department of Ear, Nose, and Throat, Erasme Hospital, Universite Libre de Brixelles, Brussels (Belgium)

Purpose: To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of VS. Methods and Materials: This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up {>=}1 year post-GKR. The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients. Results: At last hearing follow-up, 52 patients had no hearing worsening, and 30 patients had an increase of {>=}1 class on Gardner-Robertson classification. We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume. Conclusions: Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of VS. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume.

• OSTI ID: 20793415
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 64; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AUDITORY ORGANS
CARCINOMAS
DOSIMETRY
PATIENTS
PRESERVATION
RADIOTHERAPY
SURGERY