Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy

Journal Article · Tue Jan 31 23:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.0· OSTI ID:20793322

Adam, Jean-Francois ^[1]; Joubert, Aurelie ^[1]; Biston, Marie-Claude ^[1]; Charvet, Anne-Marie ^[1]; Peoc'h, Michel ^[2]; Le Bas, Jean-Francois ^[1]; Balosso, Jacques ^[1]; Esteve, Francois ^[1]; Elleaume, Helene ^[3]

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1. INSERM U647, Grenoble (France)
2. Centre Hospitalier Bellevue, Departement de pathologie, Saint Etienne (France)
3. INSERM U647, Grenoble (France) and Universite Joseph Fourier, Grenoble (France) and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble (France)

Purpose: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation. Methods and Materials: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total). Results: For doses {<=}15 Gy, the intracarotid infusion of mannitol and iodine improved the rats' survival compared with intravenous injection or irradiation alone. The percentage-increased life spans (ILS) were 91%, 116%, and 169% without iodine, after infusion of iodine and mannitol intravenously, and intracarotid, respectively (15 Gy). At 25 Gy, the rats irradiated without iodine had the longest survival (ILS = 607%), but no additional benefit was obtained with iodine and mannitol. Conclusions: Iodine-enhanced SSR is significantly improved with concomitant intracarotid infusion of iodine and mannitol for radiation doses {<=}15 Gy.

• OSTI ID: 20793322
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 64; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD-BRAIN BARRIER
BRAIN
CONTRAST MEDIA
GLIOMAS
INFUSION
INTRAVENOUS INJECTION
IODINE
IRRADIATION
LIFE SPAN
RADIATION DOSES
RADIOTHERAPY
RATS
SYNCHROTRON RADIATION
SYNCHROTRON RADIATION SOURCES
SYNCHROTRONS
X RADIATION