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Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21{sup WAF1/CIP1}

Journal Article · · Biochemical and Biophysical Research Communications
DOI:https://doi.org/10.1016/J.BBRC.2005.1· OSTI ID:20793228
 [1];  [1];  [2];  [3];  [1];  [4];  [5]
  1. Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)
  2. Department of Internal Medicine, Yonsei University College of Medicine, Seoul 135-270 (Korea, Republic of)
  3. School of Life Science and Biotechnology, Korea University, Seoul 136-705 (Korea, Republic of)
  4. Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul 136-705 (Korea, Republic of)
  5. Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of) and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul 136-705 (Korea, Republic of)
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Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27{sup Kip1} in the absence of p53. This study found that MRPL41 mediates the p21{sup WAF1/CIP1}-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21{sup WAF1/CIP1} and p27{sup Kip1} levels under the growth inhibitory conditions.
OSTI ID:
20793228
Journal Information:
Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 338; ISSN BBRCA9; ISSN 0006-291X
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
CELL CYCLE
CELL PROLIFERATION
GROWTH
PROTEINS