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Title: Radiotherapy in Ewing tumors of the vertebrae: Treatment results and local relapse analysis of the Chess 81/86 and EICESS 92 trials

Abstract

Purpose: Treatment results in patients with Ewing tumors of the vertebrae enrolled in the Cooperative Ewing's Sarcoma Study (CESS) 81, 86, and the European Intergroup Cooperative Ewing's Sarcoma Study (EICESS) 92 trials were analyzed with special emphasis on radiation-associated factors. Patients and Methods: A retrospective analysis was performed on 116 patients with primary tumors of the cervical, thoracic, or lumbar vertebrae treated between 1981 and 1999. Furthermore, a relapse analysis was done on those patients who underwent radiotherapy and subsequently had a local recurrence. Results: A total of 64.6% of the patients received definitive radiotherapy; 27.5% of patients had surgery and radiotherapy. Only 4 patients (3.4%) underwent definitive surgery. Twenty-seven patients presented with metastases at diagnosis. 22.4% of the total group developed a local relapse. Among the subgroup with definitive radiotherapy, local recurrence was seen in 17 of 75 patients (22.6%). Event-free survival and survival at 5 years were 47% and 58%, respectively. Of the 14 evaluable patients with a local relapse after radiotherapy, 13 were in-field. No correlation between radiation dose and local control could be found. Conclusion: Surgery with wide resection margins is rarely possible. The results after definitive radiotherapy in vertebral tumors are comparable to those ofmore » other tumor sites when definitive radiotherapy is given. Nearly all local relapses after radiotherapy are in-field.« less

Authors:
 [1];  [2];  [3];  [2];  [2];  [2];  [4];  [4];  [5];  [3];  [2]
  1. Department of Radiotherapy, University Hospital of Muenster, Muenster (Germany). E-mail: schuck@uni-muenster.de
  2. Department of Pediatric Oncology and Hematology, University Hospital of Muenster, Muenster (Germany)
  3. Department of Radiotherapy, University Hospital of Muenster, Muenster (Germany)
  4. Department of Orthopedics, University Hospital of Muenster, Muenster (Germany)
  5. Department of Radiotherapy, University Hospital of Halle, Halle (Germany)
Publication Date:
OSTI Identifier:
20788254
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.05.036; PII: S0360-3016(05)00946-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; METASTASES; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SARCOMAS; SURGERY; VERTEBRAE

Citation Formats

Schuck, Andreas, Ahrens, Susanne, Schorlemer, Ines von, Kuhlen, Michaela, Paulussen, Michael, Hunold, Andrea, Gosheger, Georg, Winkelmann, Winfried, Dunst, Juergen, Willich, Normann, and Juergens, Heribert. Radiotherapy in Ewing tumors of the vertebrae: Treatment results and local relapse analysis of the Chess 81/86 and EICESS 92 trials. United States: N. p., 2005. Web. doi:10.1016/J.IJROBP.2005.0.
Schuck, Andreas, Ahrens, Susanne, Schorlemer, Ines von, Kuhlen, Michaela, Paulussen, Michael, Hunold, Andrea, Gosheger, Georg, Winkelmann, Winfried, Dunst, Juergen, Willich, Normann, & Juergens, Heribert. Radiotherapy in Ewing tumors of the vertebrae: Treatment results and local relapse analysis of the Chess 81/86 and EICESS 92 trials. United States. doi:10.1016/J.IJROBP.2005.0.
Schuck, Andreas, Ahrens, Susanne, Schorlemer, Ines von, Kuhlen, Michaela, Paulussen, Michael, Hunold, Andrea, Gosheger, Georg, Winkelmann, Winfried, Dunst, Juergen, Willich, Normann, and Juergens, Heribert. Thu . "Radiotherapy in Ewing tumors of the vertebrae: Treatment results and local relapse analysis of the Chess 81/86 and EICESS 92 trials". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20788254,
title = {Radiotherapy in Ewing tumors of the vertebrae: Treatment results and local relapse analysis of the Chess 81/86 and EICESS 92 trials},
author = {Schuck, Andreas and Ahrens, Susanne and Schorlemer, Ines von and Kuhlen, Michaela and Paulussen, Michael and Hunold, Andrea and Gosheger, Georg and Winkelmann, Winfried and Dunst, Juergen and Willich, Normann and Juergens, Heribert},
abstractNote = {Purpose: Treatment results in patients with Ewing tumors of the vertebrae enrolled in the Cooperative Ewing's Sarcoma Study (CESS) 81, 86, and the European Intergroup Cooperative Ewing's Sarcoma Study (EICESS) 92 trials were analyzed with special emphasis on radiation-associated factors. Patients and Methods: A retrospective analysis was performed on 116 patients with primary tumors of the cervical, thoracic, or lumbar vertebrae treated between 1981 and 1999. Furthermore, a relapse analysis was done on those patients who underwent radiotherapy and subsequently had a local recurrence. Results: A total of 64.6% of the patients received definitive radiotherapy; 27.5% of patients had surgery and radiotherapy. Only 4 patients (3.4%) underwent definitive surgery. Twenty-seven patients presented with metastases at diagnosis. 22.4% of the total group developed a local relapse. Among the subgroup with definitive radiotherapy, local recurrence was seen in 17 of 75 patients (22.6%). Event-free survival and survival at 5 years were 47% and 58%, respectively. Of the 14 evaluable patients with a local relapse after radiotherapy, 13 were in-field. No correlation between radiation dose and local control could be found. Conclusion: Surgery with wide resection margins is rarely possible. The results after definitive radiotherapy in vertebral tumors are comparable to those of other tumor sites when definitive radiotherapy is given. Nearly all local relapses after radiotherapy are in-field.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 63,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}