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Title: Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice

Abstract

Asian sand dust (ASD) containing sulfate (SO{sub 4} {sup 2-}) reportedly causes adverse respiratory health effects but there is no experimental study showing the effect of ASD toward allergic respiratory diseases. The effects of ASD and ASD plus SO{sub 4} {sup 2-} toward allergic lung inflammation induced by ovalbumin (OVA) were investigated in this study. ICR mice were administered intratracheally with saline; ASD alone (sample from Shapotou desert); and ASD plus SO{sub 4} {sup 2-} (ASD-SO{sub 4}); OVA+ASD; OVA+ASD-SO{sub 4}. ASD or ASD-SO{sub 4} alone caused mild nutrophilic inflammation in the bronchi and alveoli. ASD and ASD-SO{sub 4} increased pro-inflammatory mediators, such as Keratinocyte chemoattractant (KC) and macrophage inflammatory protein (MIP)-1 alpha, in bronchoalveolar lavage fluids (BALF). ASD and ASD-SO{sub 4} enhanced eosinophil recruitment induced by OVA in the alveoli and in the submucosa of the airway, which has a goblet cell proliferation in the bronchial epithelium. However, a further increase of eosinophils by addition of SO{sub 4} {sup 2-} was not observed. The two sand dusts synergistically increased interleukin-5 (IL-5) and monocyte chemotactic protein-1 (MCP-1), which were associated with OVA, in BALF. However, the increased levels of IL-5 were lower in the OVA+ASD-SO{sub 4} group than in the OVA+ASDmore » group. ASD caused the adjuvant effects to specific-IgG1 production by OVA, but not to specific-IgE. These results suggest that the enhancement of eosinophil recruitment in the lung is mediated by synergistically increased IL-5 and MCP-1. IgG1 antibodies may play an important role in the enhancement of allergic reaction caused by OVA and sand dust. However, extra sulfate may not contribute to an increase of eosinophils.« less

Authors:
 [1];  [2];  [2];  [3];  [4];  [4];  [3];  [2];  [5];  [1];  [6]
  1. Major of Human Care Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki (Japan)
  2. Department of Health Sciences, Oita University of Nursing and Health Sciences, Notsuharu, Oita (Japan)
  3. Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki Japan (Japan)
  4. Environmental Chemistry Division, National Institute for Environmental Studies, Tsukuba, Ibaraki Japan (Japan)
  5. Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki (Japan)
  6. Department of Environmental Toxicology, University of California, Davis, CA 95616 (United States). E-mail: tshibamoto@ucdavis.edu
Publication Date:
OSTI Identifier:
20775317
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 99; Journal Issue: 3; Other Information: DOI: 10.1016/j.envres.2005.03.008; PII: S0013-9351(05)00031-9; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIBODIES; BRONCHI; CELL PROLIFERATION; DUSTS; EOSINOPHILS; EPITHELIUM; INFLAMMATION; ION CYCLOTRON-RESONANCE; LUNGS; MACROPHAGES; MICE; MONOCYTES; OVA; OVALBUMIN; SAND; SULFATES

Citation Formats

Hiyoshi, Kyoko, Ichinose, Takamichi, Sadakane, Kaori, Takano, Hirohisa, Nishikawa, Masataka, Mori, Ikuko, Yanagisawa, Rie, Yoshida, Seiichi, Kumagai, Yoshito, Tomura, Shigeo, and Shibamoto, Takayuki. Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice. United States: N. p., 2005. Web. doi:10.1016/j.envres.2005.03.008.
Hiyoshi, Kyoko, Ichinose, Takamichi, Sadakane, Kaori, Takano, Hirohisa, Nishikawa, Masataka, Mori, Ikuko, Yanagisawa, Rie, Yoshida, Seiichi, Kumagai, Yoshito, Tomura, Shigeo, & Shibamoto, Takayuki. Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice. United States. doi:10.1016/j.envres.2005.03.008.
Hiyoshi, Kyoko, Ichinose, Takamichi, Sadakane, Kaori, Takano, Hirohisa, Nishikawa, Masataka, Mori, Ikuko, Yanagisawa, Rie, Yoshida, Seiichi, Kumagai, Yoshito, Tomura, Shigeo, and Shibamoto, Takayuki. Tue . "Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice". United States. doi:10.1016/j.envres.2005.03.008.
@article{osti_20775317,
title = {Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice},
author = {Hiyoshi, Kyoko and Ichinose, Takamichi and Sadakane, Kaori and Takano, Hirohisa and Nishikawa, Masataka and Mori, Ikuko and Yanagisawa, Rie and Yoshida, Seiichi and Kumagai, Yoshito and Tomura, Shigeo and Shibamoto, Takayuki},
abstractNote = {Asian sand dust (ASD) containing sulfate (SO{sub 4} {sup 2-}) reportedly causes adverse respiratory health effects but there is no experimental study showing the effect of ASD toward allergic respiratory diseases. The effects of ASD and ASD plus SO{sub 4} {sup 2-} toward allergic lung inflammation induced by ovalbumin (OVA) were investigated in this study. ICR mice were administered intratracheally with saline; ASD alone (sample from Shapotou desert); and ASD plus SO{sub 4} {sup 2-} (ASD-SO{sub 4}); OVA+ASD; OVA+ASD-SO{sub 4}. ASD or ASD-SO{sub 4} alone caused mild nutrophilic inflammation in the bronchi and alveoli. ASD and ASD-SO{sub 4} increased pro-inflammatory mediators, such as Keratinocyte chemoattractant (KC) and macrophage inflammatory protein (MIP)-1 alpha, in bronchoalveolar lavage fluids (BALF). ASD and ASD-SO{sub 4} enhanced eosinophil recruitment induced by OVA in the alveoli and in the submucosa of the airway, which has a goblet cell proliferation in the bronchial epithelium. However, a further increase of eosinophils by addition of SO{sub 4} {sup 2-} was not observed. The two sand dusts synergistically increased interleukin-5 (IL-5) and monocyte chemotactic protein-1 (MCP-1), which were associated with OVA, in BALF. However, the increased levels of IL-5 were lower in the OVA+ASD-SO{sub 4} group than in the OVA+ASD group. ASD caused the adjuvant effects to specific-IgG1 production by OVA, but not to specific-IgE. These results suggest that the enhancement of eosinophil recruitment in the lung is mediated by synergistically increased IL-5 and MCP-1. IgG1 antibodies may play an important role in the enhancement of allergic reaction caused by OVA and sand dust. However, extra sulfate may not contribute to an increase of eosinophils.},
doi = {10.1016/j.envres.2005.03.008},
journal = {Environmental Research},
number = 3,
volume = 99,
place = {United States},
year = {Tue Nov 15 00:00:00 EST 2005},
month = {Tue Nov 15 00:00:00 EST 2005}
}