AAPM TG-43U1 formalism adaptation and Monte Carlo dosimetry simulations of multiple-radionuclide brachytherapy sources

Journal Article · Sat Apr 15 04:00:00 EDT 2006 · Medical Physics

DOI:https://doi.org/10.1118/1.2184438· OSTI ID:20775110

Nuttens, V E; Lucas, S ^[1]

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1. Laboratoire d'Analyses par Reactions Nucleaires, University of Namur (FUNDP), Physics Department, LARN Lab, Rue de Bruxelles, 61, B-5000 Namur (Belgium)

This paper presents a preliminary study on multiple-radionuclide sources for brachytherapy. An adaptation of the AAPM TG-43U1 formalism is proposed in order to derive the dosimetry parameters of multiple-radionuclide sources from mono-radionuclides. The adapted formalism is applied to a bi-radionuclide case with the help of Monte Carlo calculations (MCNPX 2.5.0). InterSource{sup TM} seed loaded with {sup 103}Pd and {sup 125}I was chosen. This combination promotes a higher dose rate than InterSource{sup 125} (loaded with {sup 125}I) and deeper tissue penetration than InterSource{sup 103} (loaded with {sup 103}Pd) while reducing the dose at long distance (beyond 2.5 cm) relative to InterSource{sup 125}. In conclusion, this work shows the benefits of combining different radionuclides inside the same seed and proposes an adaptation of the AAPM TG-43U1 formalism for the implementation of multiple-radionuclide sources in current treatment planning systems.

• OSTI ID: 20775110
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 4 Vol. 33; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
DOSE RATES
DOSIMETRY
IODINE 125
MONTE CARLO METHOD
PALLADIUM 103
PLANNING
RADIATION DOSES
RADIATION SOURCE IMPLANTS
SIMULATION