Dual-energy digital mammography for calcification imaging: Scatter and nonuniformity corrections

Journal Article · Tue Nov 15 04:00:00 EST 2005 · Medical Physics

DOI:https://doi.org/10.1118/1.2064767· OSTI ID:20726903

Kappadath, S Cheenu; Shaw, Chris C ^[1]

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1. Department of Imaging Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States)

Mammographic images of small calcifications, which are often the earliest signs of breast cancer, can be obscured by overlapping fibroglandular tissue. We have developed and implemented a dual-energy digital mammography (DEDM) technique for calcification imaging under full-field imaging conditions using a commercially available aSi:H/CsI:Tl flat-panel based digital mammography system. The low- and high-energy images were combined using a nonlinear mapping function to cancel the tissue structures and generate the dual-energy (DE) calcification images. The total entrance-skin exposure and mean-glandular dose from the low- and high-energy images were constrained so that they were similar to screening-examination levels. To evaluate the DE calcification image, we designed a phantom using calcium carbonate crystals to simulate calcifications of various sizes (212-425 {mu}m) overlaid with breast-tissue-equivalent material 5 cm thick with a continuously varying glandular-tissue ratio from 0% to 100%. We report on the effects of scatter radiation and nonuniformity in x-ray intensity and detector response on the DE calcification images. The nonuniformity was corrected by normalizing the low- and high-energy images with full-field reference images. Correction of scatter in the low- and high-energy images significantly reduced the background signal in the DE calcification image. Under the current implementation of DEDM, utilizing the mammography system and dose level tested, calcifications in the 300-355 {mu}m size range were clearly visible in DE calcification images. Calcification threshold sizes decreased to the 250-280 {mu}m size range when the visibility criteria were lowered to barely visible. Calcifications smaller than {approx}250 {mu}m were usually not visible in most cases. The visibility of calcifications with our DEDM imaging technique was limited by quantum noise, not system noise.

• OSTI ID: 20726903
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 11 Vol. 32; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
IMAGES
MAMMARY GLANDS
NEOPLASMS
NOISE
PHANTOMS
RADIATION DOSES
SKIN
TISSUE-EQUIVALENT MATERIALS