HCV associated glomerulopathy in Egyptian patients: clinicopathological analysis

Journal Article · Wed Mar 30 04:00:00 EST 2005 · Virology

DOI:https://doi.org/10.1016/j.virol.2005.01.013· OSTI ID:20726012

Sabry, Alaa ^[1]; E-Agroudy, Amgd ^[1]; Sheashaa, Hussein ^[1]; El-husseini, Amr ^[1]; Mohamed Taha, Nohir ^[2]; Elbaz, Mahmoud ^[2]; Sobh, Mohamed ^[1]

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1. Nephrology Department, Mansoura Urology and Nephrology Center, Mansoura University (Egypt)
2. Pathology Department, Mansoura Urology and Nephrology Center, Mansoura University (Egypt)

Background: Hepatitis C virus (HCV) infection in Egypt has reached an epidemic proportion and is associated with many extra hepatic manifestations; Glomerulonephritis (GN) is one of the most consequences of HCV infection often resulting in end stage renal disease in some cases. Detection of viral genome or particles within the kidney biopsies from HCV-infected patients has proven to be difficult. Histological characterization of renal lesions still represents a major challenge. The aim of our work was to describe the histological pattern of HCV-associated nephropathy. Methods: Fifty Patients - out of 233 - presented to Mansoura Urology and Nephrology clinic with manifestations of glomerular disease were screened for HCV antibodies by a 3rd generation ELISA test. Those tested positive for HCV antibodies were confirmed by PCR for HCV-RNA and subjected to more detailed clinical, biochemical and histological study. Kidney biopsies and in appropriate cases liver biopsies were examined by LM and electron microscopy (EM). Results: Histological study of renal biopsies revealed membranoproliferative (MPGN) type 1 to be the most common lesion encountered (54%), followed by focal segmental glomerulosclerosis (FSGS) (24%), mesangioproliferative GN (18%), membranous nephropathy (MN) (4%) in that order. EM examinations of renal biopsies were successful in identifying HCV like particles in frozen renal tissue. Conclusion: HCV-associated glomerulopathy is a distinct category of glomerulonephritis. Results of LM showed some peculiar features. In addition, we were successful in location and detection of HCV particles in renal tissues by EM.

• OSTI ID: 20726012
• Journal Information: Virology, Journal Name: Virology Journal Issue: 1 Vol. 334; ISSN VIRLAX; ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIBODIES
BIOPSY
ELECTRON MICROSCOPY
ENZYME IMMUNOASSAY
HEPATITIS
KIDNEYS
LIVER
PATIENTS
POLYMERASE CHAIN REACTION
RNA
VIRUSES