Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study

Journal Article · Tue Nov 01 04:00:00 EST 2005 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2005.03.026· OSTI ID:20702178

Yorke, Ellen D ^[1]; Jackson, Andrew ^[1]; Rosenzweig, Kenneth E ^[2]; Braban, Louise ^[1]; Leibel, Steven A ^[2]; Ling, C Clifton ^[1]

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1. Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)
2. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

Purpose: To determine dosimetric factors for lung, lung subregions, and heart that correlate with radiation pneumonitis (Radiation Therapy Oncology Group Grade 3 or more) in the 78 evaluable patients from a Phase I dose escalation study (1991-2003) of three-dimensional conformal radiation therapy (3D-CRT) of non-small-cell lung cancer. Methods and Materials: There were 10 {>=}Grade 3 pneumonitis cases within 6 months after treatment. Dose-volume factors analyzed for univariate correlation with {>=}Grade 3 pneumonitis were mean dose (MD), effective uniform dose (d{sub eff}), normal tissue complication probability (NTCP), parallel model f{sub dam} and V{sub D} for 5 {<=} D {<=} 60 Gy for whole, ipsilateral, contralateral, upper and lower halves of the lungs and heart D{sub 05}, and mean and maximum doses. Results: The most significant variables (0.005 < p < 0.006) were ipsilateral lung V{sub D} for D <20 Gy. Also significant (p < 0.05) for ipsilateral lung were V{sub D} for D <50 Gy, MD, f{sub dam} and d{sub eff}; for total lung V{sub D} (D <50 Gy), MD, f{sub dam}, d{sub eff} and NTCP; for lower lung V{sub D} (D <60 Gy), MD, f{sub dam} and d{sub eff}. All variables for upper and contralateral lung were insignificant, as were heart variables. Conclusions: Previously reported correlations between severe pneumonitis and whole lung V{sub 13} and with other dose-volume factors of total lung and lower lung are confirmed. The most significant correlations were for (V{sub 05}-V{sub 13}) in ipsilateral lung.

• OSTI ID: 20702178
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 63; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
HEART
LUNGS
PATIENTS
PLANNING
PNEUMONITIS
RADIATION DOSES
RADIOTHERAPY