Early ipsilateral breast tumor recurrences after breast conservation affect survival: An analysis of the National Cancer Institute randomized trial

Journal Article · Fri Jul 01 04:00:00 EDT 2005 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2004.12.001· OSTI ID:20698579

Brooks, Joseph P ^[1]; Danforth, David N ^[2]; Albert, Paul ^[3]; Smith, Sharon L ^[1]; Camphausen, Kevin A ^[1]; Poggi, Matthew M ^[4]

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1. Radiation Oncology Branch, National Cancer Institute, Bethesda, MD (United States)
2. Surgery Branch, National Cancer Institute, Bethesda, MD (United States)
3. Biometric Research Branch, National Cancer Institute, Bethesda, MD (United States)
4. Radiation Oncology Division, National Naval Medical Center, Bethesda, MD (United States)

Purpose: To evaluate the effect of an ipsilateral breast tumor recurrence (IBTR) after breast-conservation therapy (BCT) on survival. Methods and Materials: One hundred twenty-one women were randomized to BCT. Patients with an IBTR were analyzed to determine survival. Analysis was performed with Kaplan-Meier estimates, log-rank tests, and time-dependent covariate Cox models. Results: At a median follow-up of 18.4 years, 27 patients had an IBTR. The median survival time after IBTR was 13.1 years. The 5-year survival rate was 91.8% (95% confidence interval [CI], 81.5-100%). The 10-year survival rate was 54.3% (95% CI, 35.8-82.6%). According to a Cox model with time-dependent covariates, the hazard ratio or relative risk of dying for those with an IBTR at <5.3 years after BCT relative to patients without an IBTR after BCT is 1.47 (95% CI, 1.02-2.12%; p = 0.04). The hazard ratio for those who relapse after 5.3 years is 0.59 (95% CI, 0.22-1.61%; p = 0.31). Age at randomization, original tumor size, and the presence of positive regional nodes at initial presentation were not found to be associated with decreased survival. Conclusions: There seems to be a significant association of early IBTR after BCT with decreased survival. Local control should be maximized.

• OSTI ID: 20698579
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 62; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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HEALTH HAZARDS
MAMMARY GLANDS
PATIENTS
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SURVIVAL TIME
TETRAGONAL LATTICES
TIME DEPENDENCE