Intensity-modulated radiotherapy for head-and-neck rhabdomyosarcoma

Journal Article · Fri Apr 01 04:00:00 EST 2005 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2004.08.005· OSTI ID:20696177

Wolden, Suzanne L ^[1]; Wexler, Leonard H ^[2]; Kraus, Dennis H ^[3]; Laquaglia, Michael P ^[3]; Lis, Eric ^[4]; Meyers, Paul A ^[2]

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1. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)
2. Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)
3. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)
4. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

Purpose: To determine the preliminary results of intensity-modulated radiotherapy (IMRT) for head-and-neck rhabdomyosarcoma. Methods and Materials: Twenty-eight patients underwent IMRT as a part of multimodality therapy. Twenty-one tumors were parameningeal, three were orbital, and four were in other sites. The median age was 8 years (range, 1-29 years). Most (89%) had Group III disease. Intracranial extension was present in 71% of parameningeal tumors. A 1.5-cm margin was used, and the median dose was 50.4 Gy (range, 30-55.8 Gy). Results: The actuarial 3-year survival rate for patients with parameningeal tumors was 65%. The 3-year actuarial freedom from failure rate was 95% locally, 90% in regional nodes, 88% in the central nervous system, and 80% at distant sites. No failures occurred among patients with orbit tumors; a single central nervous system failure occurred in 1 patient with a lip/cheek tumor. Disease-free survival was significantly worse for patients with alveolar histologic features (p = 0.01). Acute radiation toxicity was similar to that reported by the Intergroup Rhabdomyosarcoma Study Group. Late radiation toxicity was recorded and was mild. Conclusion: IMRT with image fusion results in outstanding local control despite the use of a reduced margin. However, survival among patients with alveolar histologic findings or intracranial extension remains unacceptably low.

• OSTI ID: 20696177
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 61; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CENTRAL NERVOUS SYSTEM
FAILURES
HEAD
IMAGES
NECK
ORAL CAVITY
PATIENTS
RADIATION DOSES
RADIOTHERAPY
TOXICITY