Dose-volume histogram analysis as predictor of radiation pneumonitis in primary lung cancer patients treated with radiotherapy

Journal Article · Fri Apr 01 04:00:00 EST 2005 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2004.08.025· OSTI ID:20696167

Fay, Michael ^[1]; Tan, Alex ^[1]; Fisher, Richard ^[2]; Mac Manus, Michael ^[1]; Wirth, Andrew ^[1]; Ball, David ^[1]

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1. Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia)
2. Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia)

Purpose: To determine the relationship between various parameters derived from lung dose-volume histogram analysis and the risk of symptomatic radiation pneumonitis (RP) in patients undergoing radical radiotherapy for primary lung cancer. Methods and Materials: The records of 156 patients with lung cancer who had been treated with radical radiotherapy ({>=}45 Gy) and for whom dose-volume histogram data were available were reviewed. The incidence of symptomatic RP was correlated with a variety of parameters derived from the dose-volume histogram data, including the volume of lung receiving 10 Gy (V{sub 10}) through 50 Gy (V{sub 50}) and the mean lung dose (MLD). Results: The rate of RP at 6 months was 15% (95% confidence interval 9-22%). On univariate analysis, only V{sub 30} (p = 0.036) and MLD (p = 0.043) were statistically significantly related to RP. V{sub 30} correlated highly positively with MLD (r = 0.96, p < 0.001). Conclusion: V{sub 30} and MLD can be used to predict the risk of RP in lung cancer patients undergoing radical radiotherapy.

• OSTI ID: 20696167
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 61; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
HEALTH HAZARDS
LUNGS
PATIENTS
PNEUMONITIS
RADIATION DOSES
RADIOTHERAPY