Revisiting Low Energy Deuteron Production of [18F] Fluoride and Fluorine for PET

Journal Article · Tue Aug 26 04:00:00 EDT 2003 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.1619896· OSTI ID:20632533

Barnhart, T E; Nickles, R J ^[1]; Roberts, A D ^[1]

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1. Medical Physics Department, University of Wisconsin, Madison, Wisconsin, 1500 North Highland Ave., Waisman Center, Madison, WI 53705 (United States)

Fluorine-18 is currently the most widely used radioisotope in PET imaging. While much attention has been paid in recent years to production methods from 18O(p,n)18F, the current work revisits production techniques using non-enriched neon targets and the 20Ne(d,{alpha})18F reaction. While this reaction was originally pursued, and ultimately replaced by the higher yielding 18O reactions, there is an opportunity using high current low-energy deuteron accelerators and the inherent simplicity of gas targetry to provide viable alternatives to the costly 18O water target systems. 18F production systems have been developed for the gas-phase 20Ne(d,{alpha})18F reaction with deuterons from a 3MV NEC 9SDH-2 electrostatic tandem accelerator. High power target systems allowing for irradiation in excess of 100uA provided [18F]F2 yields to 86% of the theoretical maximum, and [18F]F- yields with a wash-off system of 80% of the maximum.

• OSTI ID: 20632533
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 680; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

43 PARTICLE ACCELERATORS
73 NUCLEAR PHYSICS AND RADIATION PHYSICS
DEUTERON SOURCES
DEUTERONS
FLUORIDES
FLUORINE
FLUORINE 18
NEON 20 TARGET
NUCLEAR REACTION YIELD
OXYGEN 18 REACTIONS
POSITRON COMPUTED TOMOGRAPHY
TANDEM ELECTROSTATIC ACCELERATORS