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Title: Stabilized polyacrylic saccharide protein conjugates

Abstract

This invention is directed to water soluble protein polymer conjugates which are stable in hostile environments. The conjugate comprises a protein which is linked to an acrylic polymer at multiple points through saccharide linker groups. 16 figs.

Inventors:
; ;
Publication Date:
Research Org.:
University of California
OSTI Identifier:
201517
Patent Number(s):
US 5,492,821/A/
Application Number:
PAN: 7-791,915
Assignee:
Cargill, Inc., Minneapolis, MN (United States) PTO; SCA: 550200; 090900; PA: EDB-96:056062; SN: 96001551779
DOE Contract Number:
AC03-76SF00098
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 20 Feb 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 09 BIOMASS FUELS; IMMOBILIZED ENZYMES; POLYACRYLATES; BIOTECHNOLOGY; SACCHARIDES; STABILITY

Citation Formats

Callstrom, M.R., Bednarski, M.D., and Gruber, P.R. Stabilized polyacrylic saccharide protein conjugates. United States: N. p., 1996. Web.
Callstrom, M.R., Bednarski, M.D., & Gruber, P.R. Stabilized polyacrylic saccharide protein conjugates. United States.
Callstrom, M.R., Bednarski, M.D., and Gruber, P.R. 1996. "Stabilized polyacrylic saccharide protein conjugates". United States. doi:.
@article{osti_201517,
title = {Stabilized polyacrylic saccharide protein conjugates},
author = {Callstrom, M.R. and Bednarski, M.D. and Gruber, P.R.},
abstractNote = {This invention is directed to water soluble protein polymer conjugates which are stable in hostile environments. The conjugate comprises a protein which is linked to an acrylic polymer at multiple points through saccharide linker groups. 16 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1996,
month = 2
}
  • This invention is directed to water soluble protein polymer conjugates which are stabile in hostile environments. The conjugate comprises a protein which is linked to an acrylic polymer at multiple points through saccharide linker groups.
  • An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups. 19 figs.
  • An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups.
  • A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines. 19 figs.
  • A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines.