Synthesis and characterization of polylactic acid microspheres via emulsion-based processing

Damptey, Ransford; Torres, Sabrina; Cummings, Laura; Mohan, Ram V.

doi:10.1557/s43580-023-00634-x

Synthesis and characterization of polylactic acid microspheres via emulsion-based processing

Journal Article · Tue Aug 15 00:00:00 EDT 2023 · MRS Advances

DOI:https://doi.org/10.1557/s43580-023-00634-x· OSTI ID:2007160

Damptey, Ransford ^[1]; Torres, Sabrina ^[2]; Cummings, Laura ^[2]; ^[1]

North Carolina A & T State Univ., Greensboro, NC (United States)
Kansas City National Security Campus (KCNSC), Kansas City, MO (United States)

Polylactic acid (PLA) microspheres are primarily used in drug delivery applications and rarely manufactured commercially. In encapsulation, the drug encapsulation and microsphere synthesis process happen simultaneously. Simultaneous synthesis necessitates conditions that ensure the drugs to be encapsulated remain viable in the synthesis process. Here, in the present work, solid pure PLA microspheres are prepared using a repeatable centrifugal mixing method to create a single emulsion system. A planetary thinky mixer is used to achieve centrifugal mixing. PLA acts as the dispersed phase of the emulsion, whereas Polyvinyl alcohol (emulsifier) dissolved in deionized water serves as the bulk phase. The emulsions are stirred for about 4 min at 2000 rpm. Microspheres prepared by mechanical mixing are compared with microspheres prepared by centrifugal mixing. The microspheres prepared by centrifugal mixing proved to be narrower and closer to a normal distribution with a mean size (D_x 50) of 30 microns. The size distribution of planetary mixed microspheres did not change from one batch to another.

View Accepted Manuscript (DOE)

Research Organization:: Kansas City Nuclear Security Campus (KCNSC), Kansas City, MO (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: NA0002839

OSTI ID:: 2007160

Report Number(s):: NSC--614-5142

Journal Information:: MRS Advances, Journal Name: MRS Advances Vol. 8; ISSN 2059-8521

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

References (19)

An Emerging Pore-Making Strategy: Confined Swelling-Induced Pore Generation in Block Copolymer Materials Wang, Yong; Li, Fengbin Advanced Materials, Vol. 23, Issue 19 https://doi.org/10.1002/adma.201004022	journal	April 2011
Preparation and degradability of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid)/SiO₂hybrid material Wang, Hualin; Zhang, Yan; Tian, Min Journal of Applied Polymer Science, Vol. 110, Issue 6 https://doi.org/10.1002/app.28976	journal	December 2008
Stereocomplexed Polylactides Brzeziński, Marek; Biela, Tadeusz Encyclopedia of Polymeric Nanomaterials https://doi.org/10.1007/978-3-642-29648-2_394	book	January 2015
Polylactic Acid: Synthesis, Properties and Applications Avérous, L. Monomers, Polymers and Composites from Renewable Resources https://doi.org/10.1016/B978-0-08-045316-3.00021-1	book	January 2008
Functional polymer microspheres Kawaguchi, Haruma Progress in Polymer Science, Vol. 25, Issue 8 https://doi.org/10.1016/S0079-6700(00)00024-1	journal	October 2000
Preparation and characterization of poly(lactic acid)–poly(ethylene glycol)–poly(lactic acid) (PLA–PEG–PLA) microspheres for controlled release of paclitaxel Ruan, Gang; Feng, Si-Shen Biomaterials, Vol. 24, Issue 27 https://doi.org/10.1016/S0142-9612(03)00419-8	journal	December 2003
Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering Chen, Jyh-Ping; Su, Chien-Hao Acta Biomaterialia, Vol. 7, Issue 1 https://doi.org/10.1016/j.actbio.2010.08.015	journal	January 2011
Polylactic acid (PLA) controlled delivery carriers for biomedical applications Tyler, Betty; Gullotti, David; Mangraviti, Antonella Advanced Drug Delivery Reviews, Vol. 107 https://doi.org/10.1016/j.addr.2016.06.018	journal	December 2016
Stereocomplexed PLA microspheres: Control over morphology, drug encapsulation and anticancer activity Brzeziński, M.; Kost, B.; Wedepohl, S. Colloids and Surfaces B: Biointerfaces, Vol. 184 https://doi.org/10.1016/j.colsurfb.2019.110544	journal	December 2019
Preparation and characterization of hollow Fe3O4/SiO2@PEG–PLA nanoparticles for drug delivery Deng, Haijuan; Lei, Zhongli Composites Part B: Engineering, Vol. 54 https://doi.org/10.1016/j.compositesb.2013.05.010	journal	November 2013
Gas permeation properties of poly(lactic acid) revisited Bao, Lihong; Dorgan, John R.; Knauss, Dan Journal of Membrane Science, Vol. 285, Issue 1-2 https://doi.org/10.1016/j.memsci.2006.08.021	journal	November 2006
Effect of PLA grades and morphologies on hydrolytic degradation at composting temperature: Assessment of structural modification and kinetic parameters Gorrasi, Giuliana; Pantani, Roberto Polymer Degradation and Stability, Vol. 98, Issue 5 https://doi.org/10.1016/j.polymdegradstab.2013.02.005	journal	May 2013
On O2 gas permeability of PP/PLA/clay nanocomposites: A molecular dynamic simulation approach Ebadi-Dehaghani, Hassan; Barikani, Mehdi; Khonakdar, Hossein Ali Polymer Testing, Vol. 45 https://doi.org/10.1016/j.polymertesting.2015.05.010	journal	August 2015
Polylactide (PLA)-based nanocomposites Raquez, Jean-Marie; Habibi, Youssef; Murariu, Marius Progress in Polymer Science, Vol. 38, Issue 10-11 https://doi.org/10.1016/j.progpolymsci.2013.05.014	journal	October 2013
Self Assembly of Amphiphilic (PEG)₃-PLA Copolymer as Polymersomes: Preparation, Characterization, and Their Evaluation As Drug Carrier Jain, Jay Prakash; Kumar, Neeraj Biomacromolecules, Vol. 11, Issue 4 https://doi.org/10.1021/bm1000026	journal	February 2010
Microcosmic Mechanisms for Protein Incomplete Release and Stability of Various Amphiphilic mPEG-PLA Microspheres Wei, Yi; Wang, Yu Xia; Wang, Wei Langmuir, Vol. 28, Issue 39 https://doi.org/10.1021/la3017112	journal	September 2012
Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration Tobío, M.; Gref, R.; Sánchez, A. Pharmaceutical Research, Vol. 15, Issue 2, p. 270-275 https://doi.org/10.1023/A:1011922819926	journal	January 1998
Polylactic Acid in Medicine Davachi, Seyed Mohammad; Kaffashi, Babak Polymer-Plastics Technology and Engineering, Vol. 54, Issue 9 https://doi.org/10.1080/03602559.2014.979507	journal	January 2015
Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System Tham, C. Y.; Hamid, Zuratul Ain Abdul; Ahmad, Z. A. Key Engineering Materials, Vol. 594-595 https://doi.org/10.4028/www.scientific.net/KEM.594-595.214	journal	December 2013

Similar Records

Microporous structure in silicone polymers with polylactic acid and polyethylene glycol microspheres: Synthesis and characterization

Journal Article · Sun Dec 17 23:00:00 EST 2023 · MRS Advances · OSTI ID:2473193

Synthesis and Characterization of Polymeric Pore Former Microspheres using Modified Polymer Resin

Thesis/Dissertation · Fri Dec 31 23:00:00 EST 2021 · OSTI ID:1963384

Influence of extraction parameters on dispersity of hydrocarbon emulsions from tar sands

Journal Article · Sun May 01 00:00:00 EDT 1988 · Chem. Technol. Fuels Oils (Engl. Transl.); (United States) · OSTI ID:6303331

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
PLA
centrifugal mixing
emulsion
microspheres
planetary mixing

Synthesis and characterization of polylactic acid microspheres via emulsion-based processing

Citation Formats

References (19)

Similar Records

Related Subjects