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Title: Conjugate and method for forming aminomethyl phosphorus conjugates

Abstract

A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.

Authors:
; ; ; ;
Publication Date:
Sponsoring Org.:
US Department of Energy
OSTI Identifier:
20013958
Alternate Identifier(s):
OSTI ID: 20013958
DOE Contract Number:
FG02-89ER60875
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 7 Sep 1999
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; PHOSPHINES; AMINES; CHEMICAL REACTIONS; CHEMICAL BONDS; CHEMICAL PREPARATION; ORGANIC PHOSPHORUS COMPOUNDS

Citation Formats

Katti, K.V., Berning, D.E., Volkert, W.A., Ketring, A.R., and Churchill, R. Conjugate and method for forming aminomethyl phosphorus conjugates. United States: N. p., 1999. Web.
Katti, K.V., Berning, D.E., Volkert, W.A., Ketring, A.R., & Churchill, R. Conjugate and method for forming aminomethyl phosphorus conjugates. United States.
Katti, K.V., Berning, D.E., Volkert, W.A., Ketring, A.R., and Churchill, R. Tue . "Conjugate and method for forming aminomethyl phosphorus conjugates". United States. doi:.
@article{osti_20013958,
title = {Conjugate and method for forming aminomethyl phosphorus conjugates},
author = {Katti, K.V. and Berning, D.E. and Volkert, W.A. and Ketring, A.R. and Churchill, R.},
abstractNote = {A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 07 00:00:00 EDT 1999},
month = {Tue Sep 07 00:00:00 EDT 1999}
}
  • A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.
  • A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines. 19 figs.
  • A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines.
  • The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.
  • A pre-form CMC cavity and method of forming pre-form CMC cavity for a ceramic matrix component includes providing a mandrel, applying a base ply to the mandrel, laying-up at least one CMC ply on the base ply, removing the mandrel, and densifying the base ply and the at least one CMC ply. The remaining densified base ply and at least one CMC ply form a ceramic matrix component having a desired geometry and a cavity formed therein. Also provided is a method of forming a CMC component.