Gamma-irradiated bacterial preparation having anti-tumor activity

Patent · Tue Nov 16 00:00:00 EST 1999

OSTI ID:20013240

Vass, A A; Tyndall, R L; Terzaghi-Howe, P

This application describes a bacterial preparation from Pseudomonas species isolated {number{underscore}sign}15 ATCC 55638 that has been exposed to gamma radiation exhibits cytotoxicity that is specific for neoplastic carcinoma cells. A method for obtaining a bacterial preparation having antitumor activity consists of suspending a bacterial isolate in media and exposing the suspension to gamma radiation. A bacterial preparation of an aged culture of an amoeba-associated bacteria exhibits anti-reverse transcriptase activity. A method for obtaining a bacterial preparation having anti-reverse transcriptase activity from an amoeba-associated bacterial isolate grown to stationary phase is disclosed.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-96OR22464
• Assignee: PTO; EDB-00:006663
• Application Number: Int. Cl. A01N 63/00; C12Q 1/02; C12N 13/00; C12N 1/20; US 5,985,268/A/; 8-929,648; TRN: US0000984
• OSTI ID: 20013240
• Resource Relation: Other Information: PBD: 16 Nov 1999
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
THERAPEUTIC USES
TUMOR CELLS
CARCINOMAS
PSEUDOMONAS
GAMMA RADIATION
ENZYME ACTIVITY
DNA POLYMERASES
SPECIFICITY