Sex-specific vitellogenin production in immature rainbow trout

Journal Article · Fri Oct 01 04:00:00 EDT 1999 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1897/1551-5028(1999)018<2361:SSVPII>2.3.CO;2· OSTI ID:20006605

Carlson, D B; Williams, D E

Many xenobiotics interact with hormone systems of animals, potentially leading to a phenomenon commonly called endocrine disruption. Much attention has focused on steroid hormone systems and corresponding receptor proteins, particularly estrogens. Vitellogenin (Vg) was measured in sexually immature rainbow trout (Oncorhynchus mykiss) exposed to 17{beta}-estradiol (E{sub 2}) in the diet. Mixed-sex populations of trout aged 3, 6, 12, or 18 months were maintained separately and fed E{sub 2} at 0.05 or 2.5 mg/kg for 7d. Females fed E{sub 2} at 0.05 mg/kg consistently produced three- to fourfold greater amounts of Vg than similarly aged males. Age- and sex-matched fish fed E{sub 2} at 2.5 mg/kg produced equivalent amounts of Vg. Sex differences in Vg production were apparent only at a dose of E{sub 2} (0.05 mg/kg) that results in submaximal Vg induction. Their results document the importance of considering the sex of juvenile fish when using Vg production as a marker of xenoestrogen exposure.

• Research Organization: Oregon State Univ., Corvallis, OR (US)
• OSTI ID: 20006605
• Journal Information: Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 10 Vol. 18; ISSN ETOCDK; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
BIOSYNTHESIS
ESTROGENS
GLYCOPROTEINS
SEX DEPENDENCE
TROUT
WATER POLLUTION
XENOBIOTICS