Engineering Enzymes for Environmental Sustainability

Radley, Emily; Davidson, John; Foster, Jake; Obexer, Richard; Bell, Elizabeth L.; Green, Anthony P.

doi:10.1002/anie.202309305

Engineering Enzymes for Environmental Sustainability

Journal Article · Thu Aug 31 00:00:00 EDT 2023 · Angewandte Chemie

DOI:https://doi.org/10.1002/anie.202309305· OSTI ID:1998731

Radley, Emily ^[1]; Davidson, John ^[1]; Foster, Jake ^[1]; Obexer, Richard ^[1]; Bell, Elizabeth L. ^[2]; Green, Anthony P. ^[1]

Univ. of Manchester (United Kingdom)
National Renewable Energy Laboratory (NREL), Golden, CO (United States). Renewable Resources and Enabling Science Center

The development and implementation of more efficient and sustainable technologies is key to delivering our net–zero targets. Here we review how engineered enzymes, with a focus on those developed using directed evolution, can be deployed to improve the sustainability of numerous processes and help to conserve our environment. Efficient and robust biocatalysts have been engineered to capture carbon dioxide (CO2) and have been embedded into new efficient metabolic CO2 fixation pathways. Enzymes have been refined for bioremediation, enhancing their ability to degrade toxic and harmful pollutants. Biocatalytic recycling is gaining momentum, with engineered cutinases and PETases developed for the depolymerization of the abundant plastic, PET. Finally, biocatalytic approaches for accessing petroleum–based feedstocks and chemicals are expanding, using optimized enzymes to convert plant biomass into biofuels or other high value products. Finally, through these examples, we hope to illustrate how enzyme engineering and biocatalysis can contribute to the development of more environmentally sustainable approaches, in order to protect our planet.

View Accepted Manuscript (DOE)

Research Organization:: National Renewable Energy Laboratory (NREL), Golden, CO (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Energy Efficiency Office. Advanced Materials & Manufacturing Technologies Office (AMMTO); USDOE Office of Energy Efficiency and Renewable Energy (EERE), Office of Sustainable Transportation. Bioenergy Technologies Office (BETO); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC36-08GO28308

OSTI ID:: 1998731

Report Number(s):: NREL/JA-2800-87182; MainId:87957; UUID:23899ec6-21f5-4676-9c58-1204e60435e2; MainAdminID:70476

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Journal Issue: 52 Vol. 135; ISSN 0044-8249

Publisher:: German Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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