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Detection of cholinesterase inhibition with microfluidic devices and systems thereof

Patent ·
OSTI ID:1998508

The present invention relates to methods of conducting cholinesterase inhibition assays. In one instance, the assays can be configured to determine the presence of inactivated and activated cholinesterases. Also described herein are microfluidic devices and systems for conducting such assays.

Research Organization:
Sandia National Laboratories (SNL-CA), Livermore, CA (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
DOE Contract Number:
NA0003525
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Number(s):
11,680,946
Application Number:
17/143,363
OSTI ID:
1998508
Country of Publication:
United States
Language:
English

References (34)

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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) journal January 2017
An on–off–on gold nanocluster-based fluorescent probe for sensitive detection of organophosphorus pesticides journal January 2017
Thiol–ene click reaction-induced fluorescence enhancement by altering the radiative rate for assaying butyrylcholinesterase activity journal January 2019
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Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case–control study journal December 2018
Feasibility of Portable Fingerstick Cholinesterase Testing in Adolescents in South Texas journal January 2019
An Evaluation of Blood Cholinesterase Testing Methods for Military Health report May 2008
Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study journal November 2017
Construction of an Acetylcholinesterase Sensor Based on Synthesized Paramagnetic Nanoparticles, a Simple Tool for Neurotoxic Compounds Assay journal March 2017

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