Electrophoretic device and method to separate and detect analyte ions

Klavetter, Kyle C.; Siegal, Michael P.; Yelton, William G.; Perez, Carlos; Frischknecht, Amalie L.; Wanke, Michael C.

Electrophoretic device and method to separate and detect analyte ions

Patent · Tue Jun 13 04:00:00 EDT 2023

OSTI ID:1998481

Klavetter, Kyle C.; Siegal, Michael P.; Yelton, William G.; Perez, Carlos; Frischknecht, Amalie L.; Wanke, Michael C.

This invention is directed to an inexpensive, miniaturized, portable, low-power device and method for electrophoretic separation and electrochemical detection of an analyte, including different isotopes of the same element. The invention replaces a conventional or microfabricated capillary electrophoresis tube with a microchip comprising an array of parallel electrophoretic separation nanotubes or aligned hollow channels fabricated in a porous substrate.

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

DOE Contract Number:: NA0003525

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Number(s):: 11,674,925

Application Number:: 17/066,703

OSTI ID:: 1998481

Country of Publication:: United States

Language:: English

References (10)

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End-column detection for capillary zone electrophoresis Huang, Xiaohua.; Zare, Richard N.; Sloss, Sandra. Analytical Chemistry, Vol. 63, Issue 2 https://doi.org/10.1021/ac00002a020	journal	January 1991
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Automated two‐dimensional separation flow system with electrochemical preconcentration, stripping, capillary electrophoresis and contactless conductivity detection for trace metal ion analysis Lopes, Fernando Silva; Coelho, Lúcia Helena Gomes; Gutz, Ivano Gebhardt Rolf ELECTROPHORESIS, Vol. 32, Issue 8 https://doi.org/10.1002/elps.201000479	journal	March 2011
1998 W.A.E. McBryde Medal Lecture: Searching for the Holy Grail in analytical separations Lucy, Charles A.; Yeung, Ken K. -C; Fu, Shilin Canadian Journal of Chemistry, Vol. 77, Issue 3 https://doi.org/10.1139/v99-007	journal	March 1999
Electrokinetic Transport in Nanochannels. 2. Experiments Pennathur, Sumita; Santiago, Juan G. Analytical Chemistry, Vol. 77, Issue 21 https://doi.org/10.1021/ac0508346	journal	November 2005
Electrokinetic Flow in a Narrow Cylindrical Capillary Rice, C. L.; Whitehead, R. The Journal of Physical Chemistry, Vol. 69, Issue 11 https://doi.org/10.1021/j100895a062	journal	November 1965
Microfabricated capillary electrophoresis sensor for uranium (VI) Collins, Greg E.; Lu, Qin Analytica Chimica Acta, Vol. 436, Issue 2 https://doi.org/10.1016/S0003-2670(01)00903-5	journal	June 2001
Electrokinetic Transport in Nanochannels. 1. Theory Pennathur, Sumita; Santiago, Juan G. Analytical Chemistry, Vol. 77, Issue 21 https://doi.org/10.1021/ac050835y	journal	November 2005

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Electrophoretic device and method to separate and detect analyte ions

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