Evaluation of Preoperative and Intraoperative Mobile Gamma Camera Imaging in Sentinel Lymph Node Biopsy for Melanoma Independent of Preoperative Lymphoscintigraphy

Judge, Joshua M.; Popovic, Kosta; Petroni, Gina R.; Kross, Brian; McKisson, John; McKisson, Jack; Weisenberger, Andrew G.; Stolin, Alexander; Majewski, Stan; Rehm, Patrice; Slingluff, Craig L.; Williams, Mark B.; Dengel, Lynn T.

doi:10.1016/j.jss.2022.12.013

Evaluation of Preoperative and Intraoperative Mobile Gamma Camera Imaging in Sentinel Lymph Node Biopsy for Melanoma Independent of Preoperative Lymphoscintigraphy

Journal Article · Fri Jan 20 00:00:00 EST 2023 · Journal of Surgical Research

DOI:https://doi.org/10.1016/j.jss.2022.12.013· OSTI ID:1997946

Judge, Joshua M. ^[1]; Popovic, Kosta ^[1]; Petroni, Gina R. ^[1]; Kross, Brian ^[2]; McKisson, John ^[2]; McKisson, Jack ^[2]; Weisenberger, Andrew G. ^[2]; Stolin, Alexander ^[3]; Majewski, Stan ^[3]; Rehm, Patrice ^[1]; Slingluff, Craig L. ^[1]; Williams, Mark B. ^[1]; ^[1]

Univ. of Virginia, Charlottesville, VA (United States)
Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)
West Virginia Univ., Morgantown, WV (United States)

Sentinel lymph node biopsy (SLNB) is standard practice for staging cutaneous melanoma. High false negative rates have increased interest in adjunctive techniques for localizing SLNs. Mobile gamma cameras (MGCs) represent potential tools to enhance SLNB performance. Twenty eligible melanoma patients underwent 99mTc sulfur colloid injection and standard lymphoscintigraphy with a fixed gamma camera (FGC). A survey using a 20 cm square MGC, performed immediately preoperatively by the study surgeon, was used to establish an operative plan while blinded to the FGC results. Subsequently, SLNB was performed using a gamma probe and a novel 6 cm diameter handheld MGC. A total of 24 SLN basins were detected by FGC. Prior to unblinding, all 24 basins were identified with the preoperative MGC, and the operative plan established by preoperative MGC imaging was confirmed accurate by review of the FGC images. All individual SLNs were identified during intraoperative MGC imaging, and in 5/24 (21%) cases, additional clinical information was obtained from the MGC. Preoperative MGC images provide information consistent with FGC images for planning SLNB and in some cases provides additional information that aided in surgical decision-making.

View Accepted Manuscript (DOE)

Research Organization:: Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC05-06OR23177

OSTI ID:: 1997946

Alternate ID(s):: OSTI ID: 1923944

Report Number(s):: DOE/OR/23177-5189; JLAB-PHY-21-3366

Journal Information:: Journal of Surgical Research, Journal Name: Journal of Surgical Research Vol. 285; ISSN 0022-4804

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Evaluation of Preoperative and Intraoperative Mobile Gamma Camera Imaging in Sentinel Lymph Node Biopsy for Melanoma Independent of Preoperative Lymphoscintigraphy

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