Neurobehavioral symptoms in children born extremely preterm: A Swedish National Study

Serenius, Fredrik; Kaul, Ylva Fredriksson; Källén, Karin; Hafström, Maria; Ådén, Ulrika; Stjernqvist, Karin; Farooqi, Aijaz

doi:10.1111/apa.16942

Title: Neurobehavioral symptoms in children born extremely preterm: A Swedish National Study

Journal Article · Sun Aug 27 00:00:00 EDT 2023 · Acta Paediatrica (Oslo)

DOI:https://doi.org/10.1111/apa.16942· OSTI ID:1997026

^[1];

^[2]; Källén, Karin ^[3];

^[4];

^[5]; Stjernqvist, Karin ^[6];

^[7]

Department of Women's and Children's Health Uppsala University Uppsala Sweden, Department of Neonatology, Child and Adolescent Medicine Umeå University Hospital Umeå Sweden
Department of Women's and Children's Health Uppsala University Uppsala Sweden
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Lund University of Lund Lund Sweden
Department of Paediatrics, Institute of Clinical Science University of Gothenburg Gothenburg Sweden, Angered Hospital Gothenburg Sweden
Department of Women's and Children's Health Karolinska Institute Stockholm Sweden
Department of Clinical Sciences, Pediatric Section Lund University Lund Sweden, Department of Neonatal Care and Pediatric Surgery Skåne University Hospital Lund Sweden
Department of Neonatology, Child and Adolescent Medicine Umeå University Hospital Umeå Sweden

Abstract Aim To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, <27 weeks' gestation). Methods Population‐based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term‐born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental disabilities [NDD]‐free, n = 236) were compared separately. Standardised questionnaires were used to assess parental ratings of hyperactivity and attention, emotional, peer‐relation, conduct and social problems; and deficits in perception, language and memory. Results EPT children had more reported problems in all assessed neurobehavioral domains than controls, with more than three times greater odds for most outcomes. Except for conduct problems, increased problems were identified also in NDD–free children. The odds of having neurobehavioral problems in ≥3 co‐occurring domains were five (whole EPT group) and three (NDD‐free group) times higher than in controls. Conclusion EPT children with or without NDD have more neurobehavioral problems in multiple domains than term peers. Ongoing assessments of behaviour until school age or beyond should recognise early symptoms of attention, everyday social problems, perceptual, emotional or language difficulties.

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Sponsoring Organization:: USDOE

OSTI ID:: 1997026

Alternate ID(s):: OSTI ID: 1997027

Journal Information:: Acta Paediatrica (Oslo), Journal Name: Acta Paediatrica (Oslo) Vol. 112 Journal Issue: 11; ISSN 0803-5253

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: Norway

Language:: English

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