Practical yields of I-124 from different targets in the {sup 124}Te(d,2n){sup 124}I reaction and an improved recovery of Te-124
- Brookhaven National Lab., Upton, NY (United States)
Iodine-124 is a positron-emitting isotope with a longer half-life (4.2 days) which has been used in preliminary studies for PET. Monoclonal antibodies labelled with this isotope offer promise in using PET to quantitate the biodistribution of a monoclonal. The most practical way to make the I-124 on a medium energy cyclotron is from the {sup 124}Te(d,2n){sup 124}I reaction on enriched Te-124. The {sup 125}Te(d,3n){sup 124}I reaction has been used but has been found to be less desirable due to the lower yields. The extremely high cost of the enriched Te-124 demands that nearly all the target material be recovered. In this light the author has undertaken a study of yield and recovery of Te-124 based on the widely used chemistry for production of I-123 from the {sup 124}Te(p,2n){sup 123}I reaction and the recovery of the Te-124. The target used in this study was a flat plate target. The target material is pressed into a groove in an aluminum plate which is inclined at a 10{degrees} angle to the beam. The author made a direct comparison of the yields of I-124 from a pure tellurium powder target, a tellurium powder target with added aluminum, and a tellurium oxide pellet target. These three target materials give yields which are consistent with the amount of tellurium at low beam currents (i.e. the target which is 10% aluminum gives a yield of 87% of the pure tellurium target) but show deviations at higher beam currents with the aluminum doped target giving better yields. The commonly used methods of separating the 1-124 and recovery of the enriched tellurium were explored and a new method was developed which gives better recovery of tellurium-124.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 199535
- Report Number(s):
- CONF-941129--; CNN: Grant NINDS, NS 15380
- Country of Publication:
- United States
- Language:
- English
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