The living interface between synthetic biology and biomaterial design

Liu, Allen P.; Appel, Eric A.; Ashby, Paul D.; Baker, Brendon M.; Franco, Elisa; Gu, Luo; Haynes, Karmella; Joshi, Neel S.; Kloxin, April M.; Kouwer, Paul J.; Mittal, Jeetain; Morsut, Leonardo; Noireaux, Vincent; Parekh, Sapun; Schulman, Rebecca; Tang, Sindy Y.; Valentine, Megan T.; Vega, Sebastián L.; Weber, Wilfried; Stephanopoulos, Nicholas; Chaudhuri, Ovijit

doi:10.1038/s41563-022-01231-3

The living interface between synthetic biology and biomaterial design

Journal Article · Thu Mar 31 00:00:00 EDT 2022 · Nature Materials

DOI:https://doi.org/10.1038/s41563-022-01231-3· OSTI ID:1961349

; ; ; ; ; ; Haynes, Karmella; ; ; ; ; ; Noireaux, Vincent; ; Schulman, Rebecca; ; ; ; ; more »

Recent far-reaching advances in synthetic biology have yielded exciting tools for the creation of new materials. Conversely, advances in the fundamental understanding of soft-condensed matter, polymers and biomaterials offer new avenues to extend the reach of synthetic biology. The broad and exciting range of possible applications have substantial implications to address grand challenges in health, biotechnology and sustainability. Despite the potentially transformative impact that lies at the interface of synthetic biology and biomaterials, the two fields have, so far, progressed mostly separately. This Perspective provides a review of recent key advances in these two fields, and a roadmap for collaboration at the interface between the two communities. Here we highlight the near-term applications of this interface to the development of hierarchically structured biomaterials, from bioinspired building blocks to 'living' materials that sense and respond based on the reciprocal interactions between materials and embedded cells.

View Accepted Manuscript (DOE)

Research Organization:: Johns Hopkins University, Baltimore, MD (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: DARPA Engineered Living Materials Program; Dutch Ministry of Education, Culture and Science; German Research Foundation (DFG); National Institutes of Health (NIH); National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231; SC0010426; SC0010595

OSTI ID:: 1961349

Alternate ID(s):: OSTI ID: 1995196

Journal Information:: Nature Materials, Journal Name: Nature Materials Journal Issue: 4 Vol. 21; ISSN 1476-1122

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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