Sensitivity of a Subject-specific Ankle Sprain Simulation to Extrinsic Versus Intrinsic Biomechanical Factors

Yoder, Adam J.; Petrella, Anthony J.; Farrokhi, Shawn

doi:10.3389/fbioe.2021.765331

Sensitivity of a Subject-specific Ankle Sprain Simulation to Extrinsic Versus Intrinsic Biomechanical Factors

Journal Article · Wed Dec 08 00:00:00 EST 2021 · Frontiers in Bioengineering and Biotechnology

DOI:https://doi.org/10.3389/fbioe.2021.765331· OSTI ID:1983084

Yoder, Adam J. ^[1]; Petrella, Anthony J. ^[2]; Farrokhi, Shawn ^[3]

DoD-VA Extremity Trauma and Amputation Center of Excellence, San Diego, CA (United States); Naval Medical Center, San Diego, CA (United States)
Colorado School of Mines, Golden, CO (United States)
DoD-VA Extremity Trauma and Amputation Center of Excellence, San Diego, CA (United States); Naval Medical Center, San Diego, CA (United States); Uniformed Services University of the Health Sciences, Bethesda, MD (United States)

Ankle sprains are the most common musculoskeletal injury in sport and military activity, despite existing prophylactic strategies. The purpose of this report was to develop a probabilistic simulation of lateral ankle sprains during single-limb drop landing, towards accelerating innovation in ankle sprain prevention. A deterministic, subject-specific musculoskeletal model was extended with automation and probabilistic distributions on sprain-related biomechanical factors. Probabilistic simulations were generated using traditional Monte Carlo techniques and the advanced mean value method, a more computationally-efficient approach. Predicted distributions of peak ankle joint rotations, velocities, and moments borne by supporting passive structures agreed favorably with the deterministic model and with reports of real sprain biomechanics. Parameter sensitivities identified that predictions were most strongly influenced by drop height, subtalar joint posture at contact, invertor/evertor co-activation, and passive ankle stiffness. The advanced mean value method predicted confidence bounds comparable to a 1000-trial Monte Carlo simulation, and required only 14 model evaluations and 4-min processing time. The extended probabilistic simulation may be useful to virtually test new prophylactic strategies for ankle sprains, and is made available for open-source use (https://simtk.org/projects/sprain-sim).

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOD; USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1983084

Journal Information:: Frontiers in Bioengineering and Biotechnology, Journal Name: Frontiers in Bioengineering and Biotechnology Vol. 9; ISSN 2296-4185

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

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Sensitivity of a Subject-specific Ankle Sprain Simulation to Extrinsic Versus Intrinsic Biomechanical Factors

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