An Introduction to the Bootstrap
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book
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May 1994 |
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
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June 2020 |
Targeted molecular dynamics: A new approach for searching pathways of conformational transitions
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June 1994 |
Balancing Non-Equilibrium Driving with Nucleotide Selectivity at Kinetic Checkpoints in Polymerase Fidelity Control
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April 2018 |
Nonphysical sampling distributions in Monte Carlo free-energy estimation: Umbrella sampling
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journal
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February 1977 |
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
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journal
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July 2020 |
A movie of the RNA polymerase nucleotide addition cycle
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journal
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June 2009 |
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
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journal
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May 2020 |
Structure of replicating SARS-CoV-2 polymerase
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journal
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May 2020 |
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
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journal
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May 2019 |
Stepwise mechanism for transcription fidelity
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journal
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January 2010 |
Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase
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journal
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June 2020 |
Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms
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journal
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November 2012 |
The kinetic and chemical mechanism of high-fidelity DNA polymerases
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journal
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May 2010 |
Evolution of DNA Polymerase Families: Evidences for Multiple Gene Exchange Between Cellular and Viral Proteins
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journal
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June 2002 |
Automatic atom type and bond type perception in molecular mechanical calculations
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journal
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October 2006 |
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
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journal
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March 2018 |
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
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journal
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July 2020 |
Hydrogen Fluoride Elimination Chemical Laser from N,N‐Difluoromethylamine
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January 1971 |
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting
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journal
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September 2020 |
1′-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication
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journal
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January 2021 |
Promoting transparency and reproducibility in enhanced molecular simulations
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journal
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July 2019 |
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
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March 2016 |
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
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May 2020 |
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
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September 2015 |
RNA polymerase fidelity and transcriptional proofreading
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December 2009 |
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
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journal
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December 2010 |
Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases
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March 2017 |
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
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journal
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June 2017 |
On the Evolution of the Single-Subunit RNA Polymerases
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journal
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December 1997 |
Determining selection free energetics from nucleotide pre-insertion to insertion in viral T7 RNA polymerase transcription fidelity control
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journal
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March 2019 |
Development and testing of a general amber force field
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journal
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January 2004 |
A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules
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journal
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May 1995 |
Human Mitochondrial RNA Polymerase: Evaluation of the Single-Nucleotide-Addition Cycle on Synthetic RNA/DNA Scaffolds
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journal
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June 2011 |
Parmbsc1: a refined force field for DNA simulations
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journal
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November 2015 |
Are RNA Viruses Candidate Agents for the Next Global Pandemic? A Review
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January 2017 |
Comparative Protein Modelling by Satisfaction of Spatial Restraints
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December 1993 |
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions
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journal
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December 2010 |
Development of polyphosphate parameters for use with the AMBER force field
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journal
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July 2003 |
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
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May 2020 |
A modified TIP3P water potential for simulation with Ewald summation
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journal
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November 2004 |
Remdesivir for the Treatment of Covid-19 — Final Report
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November 2020 |
Canonical sampling through velocity rescaling
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January 2007 |
Host Factors in Positive-Strand RNA Virus Genome Replication
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August 2003 |
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
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journal
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June 1993 |
Efficient fidelity control by stepwise nucleotide selection in polymerase elongation Abstract: Polymerases select nucleotides
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journal
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January 2014 |
Origin and Evolution of RNA-Dependent RNA Polymerase
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September 2017 |
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
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July 2015 |
Molecular dynamics with coupling to an external bath
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October 1984 |
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
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journal
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May 2013 |
Transient State Kinetics of Transcription Elongation by T7 RNA Polymerase
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journal
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November 2006 |
Dissecting nucleotide selectivity in viral RNA polymerases
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journal
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January 2021 |
THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method
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journal
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October 1992 |
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase
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journal
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December 2020 |
Polymorphic transitions in single crystals: A new molecular dynamics method
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journal
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December 1981 |
Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
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journal
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May 2021 |
Potential Mean Force from Umbrella Sampling Simulations: What Can We Learn and What Is Missed?
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journal
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February 2019 |
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
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journal
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June 2020 |
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
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journal
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September 2020 |
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
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July 2004 |
Coronavirus biology and replication: implications for SARS-CoV-2
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October 2020 |
Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex
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April 2021 |
MDAnalysis: A toolkit for the analysis of molecular dynamics simulations
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April 2011 |
A smooth particle mesh Ewald method
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November 1995 |
A Viral T7 RNA Polymerase Ratcheting Along DNA With Fidelity Control
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journal
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January 2019 |
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
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journal
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April 2020 |
Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases
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journal
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October 2014 |
How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules?
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journal
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January 2000 |