skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase

Journal Article · · Journal of the American Chemical Society
DOI:https://doi.org/10.1021/jacs.1c10533· OSTI ID:1982051

Not provided.

Research Organization:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
OSTI ID:
1982051
Journal Information:
Journal of the American Chemical Society, Vol. 144, Issue 14; ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (44)

Current understanding of Alzheimer’s disease diagnosis and treatment journal July 2018
Successive cleavage of β-amyloid precursor protein by γ-secretase journal September 2020
Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements journal October 2008
The substrate repertoire of γ-secretase/presenilin journal September 2020
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch journal September 2001
Longer Forms of Amyloid   Protein: Implications for the Mechanism of Intramembrane Cleavage by  -Secretase journal January 2005
 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment journal October 2009
The amyloid hypothesis of Alzheimer's disease at 25 years journal March 2016
The Genetics of Alzheimer Disease journal July 2012
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase journal August 2016
Structural basis of Notch recognition by human γ-secretase journal December 2018
Recognition of the amyloid precursor protein by human γ-secretase journal January 2019
Structural Modeling of γ-Secretase Aβn Complex Formation and Substrate Processing journal January 2019
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage journal June 2019
Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production journal April 2019
Membrane Dynamics of γ-Secretase Provides a Molecular Basis for β-Amyloid Binding and Processing journal August 2017
Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP journal March 2019
γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding journal January 2019
Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach journal January 2017
Allosteric Modulation of Intact γ-Secretase Structural Dynamics journal December 2017
Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes journal January 2017
Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators journal May 2019
Uncovering the Binding Mode of γ -Secretase Inhibitors journal June 2019
A computer-simulated mechanism of familial Alzheimer’s disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase journal December 2020
Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature journal January 2020
How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations journal September 2020
Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer’s Disease on the Orthosteric Site journal June 2021
The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex journal June 2021
Mechanisms of γ-Secretase Activation and Substrate Processing journal June 2020
Gaussian Accelerated Molecular Dynamics: Unconstrained Enhanced Sampling and Free Energy Calculation journal July 2015
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues journal January 2021
Intramembrane Proteolysis of β-Amyloid Precursor Protein by γ-Secretase Is an Unusually Slow Process journal March 2015
Peptide Gaussian accelerated molecular dynamics (Pep-GaMD): Enhanced sampling and free energy and kinetics calculations of peptide binding journal October 2020
Role of Electrostatic Interactions in Binding of Peptides and Intrinsically Disordered Proteins to Their Folded Targets. 1. NMR and MD Characterization of the Complex between the c-Crk N-SH3 Domain and the Peptide Sos journal October 2014
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state journal May 2000
Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase journal June 2009
Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein journal March 1999
Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production journal October 2013
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data journal June 2013
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria journal June 2014
Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations journal September 2011
Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ journal November 2014
Structural basis of γ-secretase inhibition and modulation by small molecule drugs journal January 2021
APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain journal December 1994

Similar Records

CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production
Journal Article · Wed Apr 06 00:00:00 EDT 2005 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1982051

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1–42)
Journal Article · Fri Jun 06 00:00:00 EDT 2014 · Journal of the Royal Society Interface · OSTI ID:1982051

Effect of a Paramagnetic Spin Label on the Intrinsically Disordered Peptide Ensemble of Amyloid- β
Journal Article · Fri Sep 01 00:00:00 EDT 2017 · Biophysical Journal · OSTI ID:1982051

Related Subjects