Quantitative mapping of functional MAO-A in the brain with radioiodinated clorgyline derivative
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:198104
- Kyoto Univ. (Japan); and others
The alteration of monoamine oxidase (MAO) activity in the brain may be associated with a number of neurological and psychiatric disorders. C-11 labeled clorgyline and deprenyl have been reported as imaging agents for MAO in the human brain. In order to expand this imaging technique to SPECT, the authors have reported the synthesis and biological evaluation of a number of iodinated clorgyline derivatives. On this basis, 2,4-dichloro-6-iodo-clorgyline analog (SIC) was selected as the most potential agent for mapping MAO-A with SPECT. In this paper, quantitative mapping of functional MAO-A in the brain with this compound was estimated. Pretreatment study with clorgyline showed the selective binding to MAO-A in the brain at 24 hr post injection of I-125-SIC. Good linear correlation between the enzyme activity and the brain up-take of I-125-SIC was observed in the pretreated study with several dose of clorgyline. Furthermore, local MAO-A activity was estimated by the autoradiographic method. High MAO-A activities were observed in midbrain and pons. This result was well agreed with another reported value obtained in vitro assay. In conclusion, this compound is indicated to be variable for quantitative analysis of MAO-A in the brain with SPECT.
- OSTI ID:
- 198104
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synthesis and biodistribution of (C-11) labeled irreversible inhibitors of MAO A and B
Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain
Preferential reduction of binding of sup 125 I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6856685
Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain
Journal Article
·
Thu Oct 29 00:00:00 EDT 2015
· Neuropsychopharmacology
·
OSTI ID:1183284
Preferential reduction of binding of sup 125 I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments
Journal Article
·
Wed May 01 00:00:00 EDT 1991
· Journal of Pharmacology and Experimental Therapeutics; (USA)
·
OSTI ID:5733424