The value of 99m-Tc-HMPAO Diamox SPECT in carotid artery stenosis
- Univ. of Amsterdam (Netherlands); and others
In this prospective study, brain perfusion reserve was evaluated by Acetazolamide (Diamox) 99m-Tc-HMPAO SPECT in patients clinically suspected for carotid artery stenosis. Consecutive 99m-Tc-HMPAO brain-SPECT investigations were obtained within one hour before and after a dose of 1000 mg Acetazolamide i.v. Studies were performed with a SME 810 multidetector neuroSPECT system. After reconstruction mean counts in the parieto-temporal region were calculated on fixed regions of interest (ROI`s) in two slices. The calculated activity was corrected for injected dose 99m-Tc-HMPAO and decay. The corrected counts of the baseline study were subtracted from the post-Diamox study. The increase of perfusion was expressed as a percentage of the baseline results in the same ROI. Fifteen studies were performed in 14 patients, 3 women and 11 men, mean age 67 years, range 44-78 years. One patient was excluded because the quality of labelling was not assessed. The results of 14 studies (28 carotid arteries) were used for statistical analysis. A carotid stenosis was considered to be significant above 70% (Duplex sonography of angiography).
- OSTI ID:
- 198052
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
Similar Records
PET evaluation of cerebral blood flow reactivity in symptomatic and asymptomatic carotid artery stenosis
Evaluation of cerebral perfusion reserve using 5% CO2 and SPECT neuroperfusion imaging