Brain perfusion SPECT in comparison with regional cerebral blood flood measured by PET: Correction of non-linearity

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:198048

Tsuchida, T; Yonekura, Y; Nishizawa, S ^[1]

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1. Kyoto Univ. Faculty of Medicine (Japan); and others

It is well-known that many perfusion tracers underestimate cerebral blood flow in high flow range. Two models have been proposed to explain non-linear relationship of flow and uptake of the tracers: one takes account for permiability-surface area product (PS model), and the other back diffusion (Lassen`s model). To validate which model is feasible for I-123 IMP, Tc-99m HMPAO, and Tc-99m ECd, ratios of cerebral regions to cerebellum on each SPECT (C/Cr) were compared with those of rCBF (F/Fr) measured by PET using O-15 CO{sub 2} steady state method.

• OSTI ID: 198048
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BLOOD FLOW
BRAIN
CEREBELLUM
COMPARATIVE EVALUATIONS
IODINE 123
LABELLED COMPOUNDS
OXYGEN 15
POSITRON COMPUTED TOMOGRAPHY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SURFACE AREA
TECHNETIUM 99
TRACER TECHNIQUES
UPTAKE