Accurate three-dimensional dose calculation using a quantitative SPECT image for radioimmunotherapy

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:198024

Ogawa, K; Kanbe, N ^[1]; Uchida, I ^[2]

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1. Hosei Univ. College of Eng, Tokyo (Japan)
2. Cancer Institute, Tokyo (Japan); and others

This study was carried out to obtain an accurate dose distribution for radioimmunotherapy. In the radioimmunotherapy using gamma and beta emitter, estimation of absorbed dose in target organs and critical organs is very important. In the study we developed the dose calculation method using a point kernel function obtained from Monte Carlo simulation. The three dimensional dose distribution was calculated by the convolution of an activity distribution with the point kernel function. The accurate three dimensional activity distribution was obtained from SPECT images by correcting attenuation and scattering of gamma rays. In the attenuation correction we used Chang`s method with an accurate map of linear attenuation coefficients measured by gamma ray fanbeam transmission CT(FTCT). The FTCT scan was performed using a commercially available gammacamera system with fanbeam collimators and external line sources positioned at the focal point of each collimator. The scatter correction was performed by eliminating the counts of scattered photons from a planar image using the triple energy window (TEW) method. The quality of SPECT image was evaluated from simulations and experiments using an abdomen phantom. Moreover, the dose calculation was performed using the reconstructed three dimensional activity distributions. The results showed that accurate dose calculation was realized to the experimental data.

• OSTI ID: 198024
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ABDOMEN
COLLIMATORS
CRITICAL ORGANS
IMAGES
MONTE CARLO METHOD
PHOTONS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOIMMUNOTHERAPY
SCATTERING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY