The clinical impact of SPECT/PET co-registration with MRI in patients with brain tumors

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197883

Macapinlac, H A; Scott, A M; Zhang, J J ^[1]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (United States); and others

We wanted to evaluate the clinical impact of co-registering SPECT and PET images with MRI (Gd-DTPA) in brain tumor patients. 81 patients with known or suspected brain tumors had 168 SPECT and/or PET scans which were difficult to interpret were coregistered with MRI. A modified Pellizari/Chen surface matching algorithm was used to fit the SPECT/PET and MR images. Impact of the technique on interpretation of the scans was defined as (A) no effect, (B) moderate effect (better localize abnormal uptake to suspected tumor and distinguish normal activity from tumor), (C) basis for final interpretation (distinguish tumor from necrosis, localize biopsy site, find occult tumor, grading of tumor). Impact on patient management was defined as (A) no effect, (B) altered diagnostic/treatment decision (continuation of conservative care, or justify chemo or radiation), (C) basis for treatment (direct biopsy, surgery, and/or radiation).

• OSTI ID: 197883
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BRAIN
DTPA
EVALUATION
IMAGES
MAGNETIC RESONANCE
NECROSIS
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY
UPTAKE