Quadrupole and multi-collector ICP-MS analysis of 226Ra in brain from a radium dial painter

Arbova, D. L.; Tolmachev, S. Y.; Brockman, J. D.

doi:10.1039/d1ja00393c

Quadrupole and multi-collector ICP-MS analysis of ²²⁶Ra in brain from a radium dial painter

Journal Article · Thu May 19 00:00:00 EDT 2022 · Journal of Analytical Atomic Spectrometry

DOI:https://doi.org/10.1039/d1ja00393c· OSTI ID:1978799

Arbova, D. L. ^[1]; ^[2]; ^[3]

University of Missouri, Columbia, MO (United States); OSTI
Washington State University, Pullman, WA (United States)
University of Missouri, Columbia, MO (United States)

We report two ICP-MS methods were developed to measure the radiotoxic isotope ²²⁶Ra in brain tissues from a radium dial painter worker. The first method was a direct analysis of acid digested samples using quadrupole ICP-MS. The instrumental LOD of ²²⁶Ra was 0.1 ng kg^-1. Polyatomic interferences at m/z 226 were investigated and Pb was identified from a polyatomic interferent in an in-house sample prepared from bovine brain, with a 226/208 formation ratio of 4 × 10^-8. The quadrupole ICP-MS method was also used to measure levels of beryllium, strontium, and uranium. A second method was developed that included cation-exchange chromatography to separate ²²⁶Ra followed by analysis with sector field MC-ICP-MS. The instrumental LOD for the cation exchange method with MC-ICP-MS detection was 0.5 pg kg^-1 (19 mBq kg^-1). The measured concentrations of ²²⁶Ra in different brain regions ranged from 0.09–0.72 ng kg^-1 (3.3–27 Bq kg^-1) and radium was non-uniformly distributed in the brain.

View Accepted Manuscript (DOE)

Research Organization:: Washington State University, Pullman, WA (United States)

Sponsoring Organization:: Nuclear Regulatory Commission (USNRC); USDOE; USDOE Office of Environment, Health, Safety and Security (AU)

Grant/Contract Number:: HS0000073

OSTI ID:: 1978799

Alternate ID(s):: OSTI ID: 1870054

Journal Information:: Journal of Analytical Atomic Spectrometry, Journal Name: Journal of Analytical Atomic Spectrometry Journal Issue: 6 Vol. 37; ISSN 0267-9477

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

References (46)

Some Unrecognized Dangers in the use and Handling of Radioactive Substances: with Especial Reference to the Storage of Insoluble Products of Radium and Mesothorium in the Reticulo-Endothelial System Martland, Harrison S.; Conlon, Philip; Knef, Joseph P. Journal of the American Medical Association, Vol. 85, Issue 23 https://doi.org/10.1001/jama.1925.02670230001001	journal	December 1925
Factors affecting the electrodeposition of226Ra Whitehead, N. E.; Ditchburn, R. G.; McCabe, W. J. Journal of Radioanalytical and Nuclear Chemistry, Vol. 160, Issue 2 https://doi.org/10.1007/BF02037123	journal	July 1992
The effect of formalin fixation on the levels of brain transition metals in archived samples Schrag, Matthew; Dickson, April; Jiffry, Arshad BioMetals, Vol. 23, Issue 6 https://doi.org/10.1007/s10534-010-9359-4	journal	June 2010
Rapid method for 226Ra and 228Ra analysis in water samples Maxwell III, S. L. Journal of Radioanalytical and Nuclear Chemistry, Vol. 270, Issue 3 https://doi.org/10.1007/s10967-006-0469-y	journal	December 2006
Application of ICP-QMS for the determination of ultratrace-levels of 226Ra in geothermal water and sediment samples Tsai, Tsuey-Lin; Lin, Chun-Chih; Wang, Tsung-Yuan Journal of Radioanalytical and Nuclear Chemistry, Vol. 286, Issue 1 https://doi.org/10.1007/s10967-010-0625-2	journal	June 2010
Rapid determination of 226Ra in environmental samples Maxwell, Sherrod L.; Culligan, Brian K. Journal of Radioanalytical and Nuclear Chemistry, Vol. 293, Issue 1 https://doi.org/10.1007/s10967-012-1627-z	journal	February 2012
Rapid method for determination of 228Ra in water samples Maxwell, Sherrod L.; Culligan, Brian K.; Utsey, Robin C. Journal of Radioanalytical and Nuclear Chemistry, Vol. 295, Issue 3 https://doi.org/10.1007/s10967-012-2257-1	journal	October 2012
Rapid determination of 226Ra in emergency urine samples Maxwell, Sherrod L.; Culligan, Brian K.; Hutchison, Jay B. Journal of Radioanalytical and Nuclear Chemistry, Vol. 300, Issue 3 https://doi.org/10.1007/s10967-014-3046-9	journal	February 2014
Leaching of Trace Elements from Biological Tissue by Formalin Fixation Gellein, Kristin; Flaten, Trond Peder; Erikson, Keith M. Biological Trace Element Research, Vol. 121, Issue 3 https://doi.org/10.1007/s12011-007-8051-1	journal	October 2007
Receptor-mediated changes in intracellular [Ca2+] in cultured rat brain capillary endothelial cells Revest, Patricia A.; Joan Abbott, N.; Gillespie, J. I. Brain Research, Vol. 549, Issue 1 https://doi.org/10.1016/0006-8993(91)90614-2	journal	May 1991
Blood–brain barrier mechanisms involved in brain calcium and potassium homeostasis Keep, Richard F.; Ulanski II, Lawrence J.; Xiang, Jianming Brain Research, Vol. 815, Issue 2 https://doi.org/10.1016/S0006-8993(98)01155-X	journal	January 1999
Micro-extraction procedures for the determination of Ra-226 in well waters by SF-ICP-MS Larivière, D.; Epov, V. N.; Reiber, K. M. Analytica Chimica Acta, Vol. 528, Issue 2 https://doi.org/10.1016/j.aca.2004.09.076	journal	January 2005
Determination of 226Ra in aqueous solutions via sorption on thin films and α-spectrometry Karamanis, D.; Ioannides, K. G.; Stamoulis, K. C. Analytica Chimica Acta, Vol. 573-574 https://doi.org/10.1016/j.aca.2006.03.024	journal	July 2006
Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples Hou, Xiaolin; Roos, Per Analytica Chimica Acta, Vol. 608, Issue 2 https://doi.org/10.1016/j.aca.2007.12.012	journal	February 2008
Determination of 226Ra at low levels in environmental, urine, and human bone samples and 223Ra in bone biopsy using alpha-spectrometry and metrological traceability to 229Th/225Ra or 226Ra Straub, Marietta; Pittet, Pierre-André; Amzalag, Gaël Analytica Chimica Acta, Vol. 1031 https://doi.org/10.1016/j.aca.2018.05.007	journal	November 2018
A review of electrodeposition methods for the preparation of alpha-radiation sources Crespo, M. T. Applied Radiation and Isotopes, Vol. 70, Issue 1 https://doi.org/10.1016/j.apradiso.2011.09.010	journal	January 2012
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure Kiffer, Frederico C.; Luitel, Krishna; Tran, Fionya H. Behavioural Brain Research, Vol. 419 https://doi.org/10.1016/j.bbr.2021.113677	journal	February 2022
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response Carter, Rachel J.; Nickson, Catherine M.; Thompson, James M. International Journal of Radiation OncologyBiologyPhysics, Vol. 100, Issue 3 https://doi.org/10.1016/j.ijrobp.2017.11.012	journal	March 2018
A rapid method to determine 226Ra concentrations in Marcellus Shale produced waters using liquid scintillation counting Ajemigbitse, Moses A.; Cannon, Fred S.; Warner, Nathaniel R. Journal of Environmental Radioactivity, Vol. 220-221 https://doi.org/10.1016/j.jenvrad.2020.106300	journal	September 2020
Reference values for trace element levels in the human brain: A systematic review of the literature Ramos, Patrícia; Pinto, Edgar; Santos, Agostinho Journal of Trace Elements in Medicine and Biology, Vol. 66 https://doi.org/10.1016/j.jtemb.2021.126745	journal	July 2021
Measurements of Pu and Ra isotopes in soils and sediments by AMS Tims, S. G.; Hancock, G. J.; Wacker, L. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 223-224 https://doi.org/10.1016/j.nimb.2004.04.147	journal	August 2004
Determination of radium isotope ratios and abundances in geological samples by thermal ionization mass spectrometry Volpe, Alan M.; Olivares, Jose A.; Murrell, Michael T. Analytical Chemistry, Vol. 63, Issue 9 https://doi.org/10.1021/ac00009a015	journal	May 1991
Determination of radium in natural waters by .alpha. liquid scintillation Burnett, William C.; Tai, Wei Chieh. Analytical Chemistry, Vol. 64, Issue 15 https://doi.org/10.1021/ac00039a012	journal	August 1992
Occurrence of beryllium as a trace element in environmental materials Meehan, W. R.; Smythe, L. E. Environmental Science & Technology, Vol. 1, Issue 10 https://doi.org/10.1021/es60010a007	journal	October 1967
Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca ²⁺ , phospholipase C and mitogen-activated protein kinase: P2Y control of brain endothelial cells Albert, Jennifer L.; Boyle, John P.; Roberts, Jonathan A. British Journal of Pharmacology, Vol. 122, Issue 5 https://doi.org/10.1038/sj.bjp.0701453	journal	November 1997
Rapid, versatile and sensitive method for the quantification of radium in environmental samples through cationic extraction and inductively coupled plasma mass spectrometry Dalencourt, Claire; Michaud, Annie; Habibi, Azza Journal of Analytical Atomic Spectrometry, Vol. 33, Issue 6 https://doi.org/10.1039/C8JA00060C	journal	January 2018
Direct analysis of radium-226 in sediment by ICP-MS: an analytical challenge? Ben Yaala, Hamza; Fniter, Rihab; Foucher, Delphine Journal of Analytical Atomic Spectrometry, Vol. 34, Issue 8 https://doi.org/10.1039/C9JA00156E	journal	January 2019
Simultaneous determination of radium and uranium activities in natural water samples using liquid scintillation counting Sanchez-Cabeza, Joan-Albert The Analyst, Vol. 123, Issue 2 https://doi.org/10.1039/a704756h	journal	January 1998
Hyphenation of flow injection on-line preconcentration and ICP-MS for the rapid determination of 226Ra in natural waters BenkheddaPresent address: Health Ca, Karima; Larivière, Dominic; Scott, Spencer Journal of Analytical Atomic Spectrometry, Vol. 20, Issue 6 https://doi.org/10.1039/b414812f	journal	January 2005
Standard additions: myth and reality Ellison, Stephen L. R.; Thompson, Michael The Analyst, Vol. 133, Issue 8 https://doi.org/10.1039/b717660k	journal	January 2008
The Million Person Study, whence it came and why Boice, John D.; Cohen, Sarah S.; Mumma, Michael T. International Journal of Radiation Biology https://doi.org/10.1080/09553002.2019.1589015	journal	April 2019
Radium dial workers: back to the future Martinez, Nicole E.; Jokisch, Derek W.; Dauer, Lawrence T. International Journal of Radiation Biology https://doi.org/10.1080/09553002.2021.1917785	journal	April 2021
A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology Boice Jr., John D.; Quinn, Brian; Al-Nabulsi, Isaf International Journal of Radiation Biology, Vol. 98, Issue 4 https://doi.org/10.1080/09553002.2021.1988183	journal	November 2021
Summary of Historical Beryllium Uses and Airborne Concentration Levels at Los Alamos National Laboratory Stefaniak, Aleksandr B.; Weaver, Virginia M.; Cadorette, Maureen Applied Occupational and Environmental Hygiene, Vol. 18, Issue 9 https://doi.org/10.1080/10473220301381	journal	September 2003
Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues Bush, V. J.; Moyer, T. P.; Batts, K. P. Clinical Chemistry, Vol. 41, Issue 2 https://doi.org/10.1093/clinchem/41.2.284	journal	February 1995
Radiation Impact from Lignite Burning Due to 226Ra in Greek Coal-Fired Power Plants Papastefanou, C. Health Physics, Vol. 70, Issue 2 https://doi.org/10.1097/00004032-199602000-00005	journal	January 1996
Natural Uranium Tissue Content of Three Caucasian Males Kathren, Ronald L.; Tolmachev, Sergei Y. Health Physics, Vol. 109, Issue 3 https://doi.org/10.1097/HP.0000000000000315	journal	January 2015
Na ⁺ –Ca ²⁺ exchange and its implications for calcium homeostasis in primary cultured rat brain microvascular endothelial cells Dömötör, Eszter; Abbott, N. Joan; Adam‐Vizi, Vera The Journal of Physiology, Vol. 515, Issue 1 https://doi.org/10.1111/j.1469-7793.1999.147ad.x	journal	February 1999
Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry Van Dyke, M. V.; Martyny, J. W.; Mroz, M. M. Occupational and Environmental Medicine, Vol. 68, Issue 11 https://doi.org/10.1136/oem.2010.064220	journal	April 2011
Beryllium's Public Relations Problem: Protecting Workers When There is No Safe Exposure Level Michaels, David; Monforton, Celeste Public Health Reports, Vol. 123, Issue 1 https://doi.org/10.1177/003335490812300112	journal	January 2008
Low-level 226Ra determination in groundwater by SF-ICP-MS: optimization of separation and pre-concentration methods Copia, Lorenzo; Nisi, Stefano; Plastino, Wolfango Journal of Analytical Science and Technology, Vol. 6, Issue 1 https://doi.org/10.1186/s40543-015-0062-5	journal	June 2015
A review of the analytical methodology to determine Radium-226 and Radium-228 in drinking waters Abbasi, Akbar Radiochimica Acta, Vol. 106, Issue 10 https://doi.org/10.1515/ract-2018-2967	journal	June 2018
Solid Cancer Mortality in the Techa River Cohort (1950–2007) Schonfeld, S. J.; Krestinina, L. Y.; Epifanova, S. Radiation Research, Vol. 179, Issue 2 https://doi.org/10.1667/RR2932.1	journal	February 2013
Radium-induced malignant tumors of the mastoid and paranasal sinuses Littman, Ms; Kirsh, Ie; Keane, At American Journal of Roentgenology, Vol. 131, Issue 5 https://doi.org/10.2214/ajr.131.5.773	journal	November 1978
The Level of Radium in Human Blood Forty Years after Ingestion Lucas, H. F.; Marshall, J. H. Radiation Research, Vol. 41, Issue 3 https://doi.org/10.2307/3572850	journal	March 1970
Studies of U.S. Radium Dial Workers: An Epidemiological Classic Fry, Shirley A. Radiation Research, Vol. 150, Issue 5 https://doi.org/10.2307/3579805	journal	November 1998

Similar Records

Rapid determination of ²²⁶Ra in emergency urine samples

Journal Article · Wed Feb 26 19:00:00 EST 2014 · Journal of Radioanalytical and Nuclear Chemistry · OSTI ID:1159456

Analysis of uranium & radium in environmental samples by ICP-MS

Conference · Thu Nov 30 23:00:00 EST 1995 · OSTI ID:126722

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Quadrupole and multi-collector ICP-MS analysis of 226Ra in brain from a radium dial painter

Citation Formats

References (46)

Similar Records

Related Subjects

Quadrupole and multi-collector ICP-MS analysis of ²²⁶Ra in brain from a radium dial painter