A Monte Carlo approach for the physiologically-based toxicokinetic (PB-TK) model of waterborne pyrene in trout: Spreadsheet implementation

Conference · Sun Dec 31 04:00:00 EST 1995

OSTI ID:197566

Law, F C.P.; Achenbach, T E ^[1]

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1. Simon Fraser Univ., Burnaby, British Columbia (Canada)

The PB-TK model of waterborne pyrene in trout was developed with the aid of a Fortran-based software package, ACSL{reg_sign}. The present study utilizes the Microsoft Excel 4.0{reg_sign} spreadsheet program to introduce a new format for the model. The spreadsheet PB-TK model is validated against the original Fortran code. The spreadsheet format allows for the coupling of the model to a commercially available Monte Carlo analysis software package, Crystal Ball{reg_sign}. The Monte Carlo technique selects a value randomly from a range of values with a known probability density function (PDF) for each input parameter of the PB-TK model. The PDFs are truncated to account for natural restraints placed on the parameters. For example, upper bounds on the sum of organ volumes and blood flows are imposed by body weight and cardiac output, respectively. Sensitivity of the PB-TK model predictions to its parameters is assessed by analyzing the results of the Monte Carlo simulations. The body weight of trout is the most sensitive parameter of the PB-TK model. Results of this study also show that the Monte Carlo approach is a more realistic method of estimating the body burden or internal dose in the target organ of an exposed population of trout since fish with different body weight, exposure, and uptake can be derived from multiple simulations of the model.

• OSTI ID: 197566
• Report Number(s): CONF-9511137--; ISBN 1-880611-03-1
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
A CODES
BIOLOGICAL ACCUMULATION
MONTE CARLO METHOD
PYRENE
SENSITIVITY
TROUT
WATER POLLUTION