PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
- Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
- Contributing Organization:
- Modeling Host Responses to Understand Severe Human Virus Infections Program Project
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1971764
- Report Number(s):
- PRJ.U19AI106772; LHVFLU; LHVEBOV; LHVWNV; LHVMERS; LHVIFN
- Availability:
- rc-support@pnnl.gov
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BioProject Accession Number [NCIT:C175890]
Dataset Collection [schema:DataCatalog]
Ebolavirus [NCBITAXON:186536]
Gene expression profile data [edam.data:0928]
Human Interferon [NCIT:C20493]
Human virus [NCIT:C14317]
Immune Response [GO:0006955]
Influenza A virus [NCBITAXON:11320]
MERS-CoV [NCBITAXON:1335626]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Multi-omics [edam.topic:4021]
Omics [edam.topic:3391]
Time Sampled Measurement Datasets [IAO:0000584]
Virology [edam.topic:0781]
West Nile virus [NCBITAXON:11082]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]