Multifunctional nanopore electrode array method for characterizing and manipulating single entities in attoliter-volume enclosures

Baek, Seol; Cutri, Allison R.; Han, Donghoon; Kwon, Seung-Ryong; Reitemeier, Julius; Sundaresan, Vignesh; Bohn, Paul W.

doi:10.1063/5.0101693

Multifunctional nanopore electrode array method for characterizing and manipulating single entities in attoliter-volume enclosures

Journal Article · Tue Nov 01 04:00:00 EDT 2022 · Journal of Applied Physics

DOI:https://doi.org/10.1063/5.0101693· OSTI ID:1971653

^[1]; Cutri, Allison R. ^[2]; ^[3]; Kwon, Seung-Ryong ^[4]; ^[2]; Sundaresan, Vignesh ^[5]; ^[2]

Univ. of Notre Dame, IN (United States); University of Notre Dame
Univ. of Notre Dame, IN (United States)
The Catholic Univ. of Korea, Gyeonggi-do (South Korea)
Gyeongsang National Univ., Jinju (South Korea)
Univ. of Notre Dame, IN (United States); Univ. of Mississippi, University, MS (United States)

Structurally regular nanopore arrays fabricated to contain independently controllable annular electrodes represent a new kind of architecture capable of electrochemically addressing small collections of matter—down to the single entity (molecule, particle, and biological cell) level. Furthermore, these nanopore electrode arrays (NEAs) can also be interrogated optically to achieve single entity spectroelectrochemistry. Larger entities such as nanoparticles and single bacterial cells are investigated by dark-field scattering and potential-controlled single-cell luminescence experiments, respectively, while NEA-confined molecules are probed by single molecule luminescence. By carrying out these experiments in arrays of identically constructed nanopores, massively parallel collections of single entities can be investigated simultaneously. The multilayer metal–insulator design of the NEAs enables highly efficient redox cycling experiments with large increases in analytical sensitivity for chemical sensing applications. NEAs may also be augmented with an additional orthogonally designed nanopore layer, such as a structured block copolymer, to achieve hierarchically organized multilayer structures with multiple stimulus-responsive transport control mechanisms. Finally, NEAs constructed with a transparent bottom layer permit optical access to the interior of the nanopore, which can result in the cutoff of far-field mode propagation, effectively trapping radiation in an ultrasmall volume inside the nanopore. Furthermore, the bottom metal layer may be used as both a working electrode and an optical cladding layer, thus, producing bifunctional electrochemical zero-mode waveguide architectures capable of carrying out spectroelectrochemical investigations down to the single molecule level.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Notre Dame, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-07ER15851

OSTI ID:: 1971653

Journal Information:: Journal of Applied Physics, Journal Name: Journal of Applied Physics Journal Issue: 17 Vol. 132; ISSN 0021-8979

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

References (89)

Graphene Nanopores for Protein Sequencing Wilson, James; Sloman, Leila; He, Zhiren Advanced Functional Materials, Vol. 26, Issue 27 https://doi.org/10.1002/adfm.201601272	journal	June 2016
Higher-Order Organization by Mesoscale Self-Assembly and Transformation of Hybrid Nanostructures Cölfen, Helmut; Mann, Stephen Angewandte Chemie International Edition, Vol. 42, Issue 21 https://doi.org/10.1002/anie.200200562	journal	May 2003
Microfluidic Confinement of Single Cells of Bacteria in Small Volumes Initiates High-Density Behavior of Quorum Sensing and Growth and Reveals Its Variability Boedicker, James Q.; Vincent, Meghan E.; Ismagilov, Rustem F. Angewandte Chemie International Edition, Vol. 48, Issue 32 https://doi.org/10.1002/anie.200901550	journal	July 2009
Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells Yu, Ru‐Jia; Ying, Yi‐Lun; Gao, Rui Angewandte Chemie International Edition, Vol. 58, Issue 12 https://doi.org/10.1002/anie.201803229	journal	March 2019
Biological Nanopore Approach for Single‐Molecule Protein Sequencing Hu, Zheng‐Li; Huo, Ming‐Zhu; Ying, Yi‐Lun Angewandte Chemie International Edition, Vol. 60, Issue 27 https://doi.org/10.1002/anie.202013462	journal	February 2021
Electrochemical Desalination for a Sustainable Water Future Knust, Kyle N.; Hlushkou, Dzmitry; Tallarek, Ulrich ChemElectroChem, Vol. 1, Issue 5 https://doi.org/10.1002/celc.201300236	journal	March 2014
Counting and Sizing of Single Vesicles/Liposomes by Electrochemical Events Liu, Yang; Xu, Cong; Yu, Ping ChemElectroChem, Vol. 5, Issue 20 https://doi.org/10.1002/celc.201800616	journal	July 2018
Convective Delivery of Electroactive Species to Annular Nanoband Electrodes Embedded in Nanocapillary-Array Membranes Gibson, Larry R.; Branagan, Sean P.; Bohn, Paul W. Small, Vol. 9, Issue 1 https://doi.org/10.1002/smll.201200237	journal	August 2012
Controlled Vectorial Electron Transfer and Photoelectrochemical Applications of Layered Relay/Photosensitizer-Imprinted Au Nanoparticle Architectures on Electrodes Metzger, Tzuriel S.; Tel-Vered, Ran; Willner, Itamar Small, Vol. 12, Issue 12 https://doi.org/10.1002/smll.201503077	journal	January 2016
Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays Fu, Kaiyu; Han, Donghoon; Crouch, Garrison M. Small, Vol. 14, Issue 18 https://doi.org/10.1002/smll.201703248	journal	January 2018
Electrowetting‐Mediated Transport to Produce Electrochemical Transistor Action in Nanopore Electrode Arrays Kwon, Seung‐Ryong; Baek, Seol; Fu, Kaiyu Small, Vol. 16, Issue 18 https://doi.org/10.1002/smll.201907249	journal	April 2020
Ionic transport in nanocapillary membrane systems Swaminathan, Vikhram V.; Gibson, Larry R.; Pinti, Marie Journal of Nanoparticle Research, Vol. 14, Issue 8 https://doi.org/10.1007/s11051-012-0951-0	journal	July 2012
World Health Organization Report: Current Crisis of Antibiotic Resistance Talebi Bezmin Abadi, Amin; Rizvanov, Albert A.; Haertlé, Thomas BioNanoScience, Vol. 9, Issue 4 https://doi.org/10.1007/s12668-019-00658-4	journal	August 2019
Biomedical surface science: Foundations to frontiers Castner, David G.; Ratner, Buddy D. Surface Science, Vol. 500, Issue 1-3 https://doi.org/10.1016/S0039-6028(01)01587-4	journal	March 2002
Mediator-free triple-enzyme cascade electrocatalytic aptasensor with exonuclease-assisted target recycling and hybridization chain reaction amplification Peng, Kanfu; Zhao, Hongwen; Yuan, Yali Biosensors and Bioelectronics, Vol. 55 https://doi.org/10.1016/j.bios.2013.12.008	journal	May 2014
Metal enhanced fluorescence improved protein and DNA detection by zigzag Ag nanorod arrays Ji, Xiaofan; Xiao, Chenyu; Lau, Wai-Fung Biosensors and Bioelectronics, Vol. 82 https://doi.org/10.1016/j.bios.2016.04.022	journal	August 2016
Stochasticity in single-entity electrochemistry Ren, Hang; Edwards, Martin A. Current Opinion in Electrochemistry, Vol. 25 https://doi.org/10.1016/j.coelec.2020.08.014	journal	February 2021
Optical-facilitated single-entity electrochemistry Wang, Hao-Wei; Lu, Si-Min; Chen, Mengjie Current Opinion in Electrochemistry, Vol. 34 https://doi.org/10.1016/j.coelec.2022.100999	journal	August 2022
A strategy for selective detection based on interferent depleting and redox cycling using the plane-recessed microdisk array electrodes Zhu, Feng; Yan, Jiawei; Lu, Miao Electrochimica Acta, Vol. 56, Issue 24 https://doi.org/10.1016/j.electacta.2011.05.129	journal	October 2011
Single-enzyme kinetics with fluorogenic substrates: lessons learnt and future directions Turunen, Petri; Rowan, Alan E.; Blank, Kerstin FEBS Letters, Vol. 588, Issue 19 https://doi.org/10.1016/j.febslet.2014.06.021	journal	June 2014
Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales Schuler, Benjamin; Hofmann, Hagen Current Opinion in Structural Biology, Vol. 23, Issue 1 https://doi.org/10.1016/j.sbi.2012.10.008	journal	February 2013
Zero-mode waveguides: Sub-wavelength nanostructures for single molecule studies at high concentrations Moran-Mirabal, Jose M.; Craighead, Harold G. Methods, Vol. 46, Issue 1 https://doi.org/10.1016/j.ymeth.2008.05.010	journal	September 2008
Three DNA sequencing methods using capillary gel electrophoresis and laser-induced fluorescence Swerdlow, Harold.; Zhang, Jian Zhong.; Chen, Da Yong. Analytical Chemistry, Vol. 63, Issue 24 https://doi.org/10.1021/ac00024a006	journal	December 1991
Digital simulation of the measured electrochemical response of reversible redox couples at microelectrode arrays: consequences arising from closely spaced ultramicroelectrodes Bard, Allen J.; Crayston, Joseph A.; Kittlesen, Gregg P. Analytical Chemistry, Vol. 58, Issue 11 https://doi.org/10.1021/ac00124a045	journal	August 1986
Construction and use of paired and triple band microelectrodes in solutions of low ionic strength Bartelt, Joan E.; Deakin, Mark R.; Amatore, Christian. Analytical Chemistry, Vol. 60, Issue 19 https://doi.org/10.1021/ac00170a040	journal	October 1988
Electrochemical behavior of reversible redox species at interdigitated array electrodes with different geometries: consideration of redox cycling and collection efficiency Niwa, Osamu.; Morita, Masao.; Tabei, Hisao. Analytical Chemistry, Vol. 62, Issue 5 https://doi.org/10.1021/ac00204a006	journal	March 1990
Self-Contained Microelectrochemical Immunoassay for Small Volumes Using Mouse IgG as a Model System Aguilar, Zoraida P.; Vandaveer, Walter R.; Fritsch, Ingrid Analytical Chemistry, Vol. 74, Issue 14 https://doi.org/10.1021/ac0110348	journal	July 2002
Recessed Ring–Disk Nanoelectrode Arrays Integrated in Nanofluidic Structures for Selective Electrochemical Detection Ma, Chaoxiong; Contento, Nicholas M.; Gibson, Larry R. Analytical Chemistry, Vol. 85, Issue 20 https://doi.org/10.1021/ac402417w	journal	September 2013
Nanofluidic Redox Cycling Amplification for the Selective Detection of Catechol Wolfrum, Bernhard; Zevenbergen, Marcel; Lemay, Serge Analytical Chemistry, Vol. 80, Issue 4 https://doi.org/10.1021/ac7016647	journal	February 2008
Microfabricated Porous Membrane Structure for Sample Concentration and Electrophoretic Analysis Khandurina, Julia; Jacobson, Stephen C.; Waters, Larry C. Analytical Chemistry, Vol. 71, Issue 9 https://doi.org/10.1021/ac981161c	journal	May 1999
Single Entity Electrochemistry in Nanopore Electrode Arrays: Ion Transport Meets Electron Transfer in Confined Geometries Fu, Kaiyu; Kwon, Seung-Ryong; Han, Donghoon Accounts of Chemical Research, Vol. 53, Issue 4 https://doi.org/10.1021/acs.accounts.9b00543	journal	January 2020
Single Molecule Electrochemical Detection in Aqueous Solutions and Ionic Liquids Byers, Joshua C.; Paulose Nadappuram, Binoy; Perry, David Analytical Chemistry, Vol. 87, Issue 20 https://doi.org/10.1021/acs.analchem.5b02569	journal	October 2015
Rapid Identification of Pseudomonas spp. via Raman Spectroscopy Using Pyoverdine as Capture Probe Pahlow, Susanne; Stöckel, Stephan; Pollok, Sibyll Analytical Chemistry, Vol. 88, Issue 3 https://doi.org/10.1021/acs.analchem.5b02829	journal	January 2016
Capture of Single Silver Nanoparticles in Nanopore Arrays Detected by Simultaneous Amperometry and Surface-Enhanced Raman Scattering Kim, Ju-Young; Han, Donghoon; Crouch, Garrison M. Analytical Chemistry, Vol. 91, Issue 7 https://doi.org/10.1021/acs.analchem.8b05748	journal	March 2019
Emulsion Solvent Evaporation-Induced Self-Assembly of Block Copolymers Containing pH-Sensitive Block Wu, Yuqing; Wang, Ke; Tan, Haiying Langmuir, Vol. 33, Issue 38 https://doi.org/10.1021/acs.langmuir.7b02330	journal	August 2017
Ion Gating in Nanopore Electrode Arrays with Hierarchically Organized pH-Responsive Block Copolymer Membranes Baek, Seol; Kwon, Seung-Ryong; Fu, Kaiyu ACS Applied Materials & Interfaces, Vol. 12, Issue 49 https://doi.org/10.1021/acsami.0c12926	journal	November 2020
Light as Trigger for Biocatalysis: Photonic Wiring of Flavin Adenine Dinucleotide-Dependent Glucose Dehydrogenase to Quantum Dot-Sensitized Inverse Opal TiO ₂ Architectures via Redox Polymers Riedel, Marc; Parak, Wolfgang J.; Ruff, Adrian ACS Catalysis, Vol. 8, Issue 6 https://doi.org/10.1021/acscatal.8b00951	journal	April 2018
Asymmetric Nafion-Coated Nanopore Electrode Arrays as Redox-Cycling-Based Electrochemical Diodes Fu, Kaiyu; Han, Donghoon; Kwon, Seung-Ryong ACS Nano, Vol. 12, Issue 9 https://doi.org/10.1021/acsnano.8b03751	journal	August 2018
Redox Cycling in Individually Encapsulated Attoliter-Volume Nanopores Kwon, Seung-Ryong; Fu, Kaiyu; Han, Donghoon ACS Nano, Vol. 12, Issue 12 https://doi.org/10.1021/acsnano.8b08693	journal	November 2018
Intelligent Dual-Responsive Cellulose Surfaces via Surface-Initiated ATRP Lindqvist, Josefina; Nyström, Daniel; Östmark, Emma Biomacromolecules, Vol. 9, Issue 8 https://doi.org/10.1021/bm800193n	journal	August 2008
Electrokinetic Flow in a Narrow Cylindrical Capillary Rice, C. L.; Whitehead, R. The Journal of Physical Chemistry, Vol. 69, Issue 11 https://doi.org/10.1021/j100895a062	journal	November 1965
Light-Harvesting Conjugated Microporous Polymers: Rapid and Highly Efficient Flow of Light Energy with a Porous Polyphenylene Framework as Antenna Chen, Long; Honsho, Yoshihito; Seki, Shu Journal of the American Chemical Society, Vol. 132, Issue 19 https://doi.org/10.1021/ja100327h	journal	March 2010
Enhanced Mass Transport of Electroactive Species to Annular Nanoband Electrodes Embedded in Nanocapillary Array Membranes Branagan, Sean P.; Contento, Nicholas M.; Bohn, Paul W. Journal of the American Chemical Society, Vol. 134, Issue 20 https://doi.org/10.1021/ja3017158	journal	May 2012
Chemical Noise Produced by Equilibrium Adsorption/Desorption of Surface Pyridine at Au–Ag–Au Bimetallic Atom-Scale Junctions Studied by Fluctuation Spectroscopy Hwang, Tai-Wei; Branagan, Sean P.; Bohn, Paul W. Journal of the American Chemical Society, Vol. 135, Issue 11 https://doi.org/10.1021/ja400567j	journal	March 2013
Redox Cycling on Recessed Ring-Disk Nanoelectrode Arrays in the Absence of Supporting Electrolyte Ma, Chaoxiong; Contento, Nicholas M.; Bohn, Paul W. Journal of the American Chemical Society, Vol. 136, Issue 20 https://doi.org/10.1021/ja502052s	journal	May 2014
Ultrafast Dynamics of Flavins in Five Redox States Kao, Ya-Ting; Saxena, Chaitanya; He, Ting-Fang Journal of the American Chemical Society, Vol. 130, Issue 39 https://doi.org/10.1021/ja8045469	journal	October 2008
Ozonolysis Is the Primary Cause of UV Photooxidation of Alkanethiolate Monolayers at Low Irradiance Zhang, Yumo; Terrill, Roger H.; Tanzer, Troy A. Journal of the American Chemical Society, Vol. 120, Issue 11 https://doi.org/10.1021/ja9714853	journal	March 1998
Engineered Asymmetric Heterogeneous Membrane: A Concentration-Gradient-Driven Energy Harvesting Device Zhang, Zhen; Kong, Xiang-Yu; Xiao, Kai Journal of the American Chemical Society, Vol. 137, Issue 46 https://doi.org/10.1021/jacs.5b09918	journal	November 2015
Perspective and Prospectus on Single-Entity Electrochemistry Baker, Lane A. Journal of the American Chemical Society, Vol. 140, Issue 46 https://doi.org/10.1021/jacs.8b09747	journal	November 2018
Mass Transport to Nanoelectrode Arrays and Limitations of the Diffusion Domain Approach: Theory and Experiment Godino, Neus; Borrisé, Xavier; Muñoz, Francesc Xavier The Journal of Physical Chemistry C, Vol. 113, Issue 25 https://doi.org/10.1021/jp9031354	journal	June 2009
Organization of Au Colloids as Monolayer Films onto ITO Glass Surfaces: Application of the Metal Colloid Films as Base Interfaces To Construct Redox-Active Monolayers Doron, Amihood; Katz, Eugenii; Willner, Itamar Langmuir, Vol. 11, Issue 4 https://doi.org/10.1021/la00004a044	journal	April 1995
Manipulating Molecular Transport through Nanoporous Membranes by Control of Electrokinetic Flow: Effect of Surface Charge Density and Debye Length Kuo, Tzu-Chi; Sloan, Lisa A.; Sweedler, Jonathan V. Langmuir, Vol. 17, Issue 20 https://doi.org/10.1021/la010429j	journal	October 2001
Selective Capture and Identification of Pathogenic Bacteria Using an Immobilized Siderophore Doorneweerd, Derek D.; Henne, Walter A.; Reifenberger, Ronald G. Langmuir, Vol. 26, Issue 19 https://doi.org/10.1021/la101962w	journal	October 2010
Rectification of Ionic Current in a Nanofluidic Diode Karnik, Rohit; Duan, Chuanhua; Castelino, Kenneth Nano Letters, Vol. 7, Issue 3 https://doi.org/10.1021/nl062806o	journal	March 2007
Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes Yameen, Basit; Ali, Mubarak; Neumann, Reinhard Nano Letters, Vol. 9, Issue 7 https://doi.org/10.1021/nl901403u	journal	July 2009
Voltage-Gated Hydrophobic Nanopores Smirnov, Sergei N.; Vlassiouk, Ivan V.; Lavrik, Nickolay V. ACS Nano, Vol. 5, Issue 9 https://doi.org/10.1021/nn202392d	journal	August 2011
Redox Cycling in Nanoscale-Recessed Ring-Disk Electrode Arrays for Enhanced Electrochemical Sensitivity Ma, Chaoxiong; Contento, Nicholas M.; Gibson, Larry R. ACS Nano, Vol. 7, Issue 6 https://doi.org/10.1021/nn401542x	journal	May 2013
Sequence-specific detection of individual DNA strands using engineered nanopores Howorka, Stefan; Cheley, Stephen; Bayley, Hagan Nature Biotechnology, Vol. 19, Issue 7 https://doi.org/10.1038/90236	journal	July 2001
Surface plasmon subwavelength optics Barnes, William L.; Dereux, Alain; Ebbesen, Thomas W. Nature, Vol. 424, Issue 6950, p. 824-830 https://doi.org/10.1038/nature01937	journal	August 2003
Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms Zhao, Kun; Tseng, Boo Shan; Beckerman, Bernard Nature, Vol. 497, Issue 7449 https://doi.org/10.1038/nature12155	journal	May 2013
The potential and challenges of nanopore sequencing Branton, Daniel; Deamer, David W.; Marziali, Andre Nature Biotechnology, Vol. 26, Issue 10 https://doi.org/10.1038/nbt.1495	journal	October 2008
A nanopore machine promotes the vectorial transport of DNA across membranes Franceschini, Lorenzo; Soskine, Misha; Biesemans, Annemie Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms3415	journal	September 2013
Electric-field-induced wetting and dewetting in single hydrophobic nanopores Powell, Matthew R.; Cleary, Leah; Davenport, Matthew Nature Nanotechnology, Vol. 6, Issue 12 https://doi.org/10.1038/nnano.2011.189	journal	October 2011
Stimuli-responsive smart gating membranes Liu, Zhuang; Wang, Wei; Xie, Rui Chemical Society Reviews, Vol. 45, Issue 3 https://doi.org/10.1039/C5CS00692A	journal	January 2016
Single occupancy spectroelectrochemistry of freely diffusing flavin mononucleotide in zero-dimensional nanophotonic structures Zaino, Lawrence P.; Grismer, Dane A.; Han, Donghoon Faraday Discussions, Vol. 184 https://doi.org/10.1039/C5FD00072F	journal	January 2015
Electrochemistry at single molecule occupancy in nanopore-confined recessed ring-disk electrode arrays Fu, Kaiyu; Han, Donghoon; Ma, Chaoxiong Faraday Discussions, Vol. 193 https://doi.org/10.1039/C6FD00062B	journal	January 2016
Selective protein trapping within hybrid nanowells Messina, G. M. L.; Passiu, C.; Rossi, A. Nanoscale, Vol. 8, Issue 36 https://doi.org/10.1039/C6NR04823D	journal	January 2016
Ion selective redox cycling in zero-dimensional nanopore electrode arrays at low ionic strength Fu, Kaiyu; Han, Donghoon; Ma, Chaoxiong Nanoscale, Vol. 9, Issue 16 https://doi.org/10.1039/C7NR00206H	journal	January 2017
(Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures Ahmadi, Yasaman; De Llano, Elisa; Barišić, Ivan Nanoscale, Vol. 10, Issue 16 https://doi.org/10.1039/C7NR09461B	journal	January 2018
Single-molecule spectroelectrochemical cross-correlation during redox cycling in recessed dual ring electrode zero-mode waveguides Han, Donghoon; Crouch, Garrison M.; Fu, Kaiyu Chemical Science, Vol. 8, Issue 8 https://doi.org/10.1039/C7SC02250F	journal	January 2017
Porous block copolymer separation membranes for 21st century sanitation and hygiene Guo, Leiming; Wang, Yong; Steinhart, Martin Chemical Society Reviews, Vol. 50, Issue 11 https://doi.org/10.1039/D0CS00500B	journal	January 2021
Acid–base chemistry at the single ion limit Sundaresan, Vignesh; Bohn, Paul W. Chemical Science, Vol. 11, Issue 40 https://doi.org/10.1039/D0SC03756G	journal	January 2020
Potential-induced wetting and dewetting in pH-responsive block copolymer membranes for mass transport control Kwon, Seung-Ryong; Baek, Seol; Bohn, Paul W. Faraday Discussions, Vol. 233 https://doi.org/10.1039/D1FD00048A	journal	January 2022
Redox cycling with facing interdigitated array electrodes as a method for selective detection of redox species Dam, V. A. T.; Olthuis, W.; van den Berg, A. The Analyst, Vol. 132, Issue 4 https://doi.org/10.1039/b616667a	journal	January 2007
Isolation, incubation, and parallel functional testing and identification by FISH of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement Liu, Weishan; Kim, Hyun Jung; Lucchetta, Elena M. Lab on a Chip, Vol. 9, Issue 15 https://doi.org/10.1039/b904958d	journal	January 2009
Potential-dependent single molecule blinking dynamics for flavin adenine dinucleotide covalently immobilized in zero-mode waveguide array of working electrodes Zhao, Jing; Zaino III, Lawrence P.; Bohn, Paul W. Faraday Discussions, Vol. 164 https://doi.org/10.1039/c3fd00013c	journal	January 2013
Counting and Sizing of Submicron Particles by the Resistive Pulse Technique DeBlois, R. W.; Bean, C. P. Review of Scientific Instruments, Vol. 41, Issue 7 https://doi.org/10.1063/1.1684724	journal	July 1970
Electrolytic transport through a synthetic nanometer-diameter pore Ho, C.; Qiao, R.; Heng, J. B. Proceedings of the National Academy of Sciences, Vol. 102, Issue 30 https://doi.org/10.1073/pnas.0500796102	journal	July 2005
Electrochemical attosyringe Laforge, F. O.; Carpino, J.; Rotenberg, S. A. Proceedings of the National Academy of Sciences, Vol. 104, Issue 29 https://doi.org/10.1073/pnas.0705102104	journal	July 2007
A programmable droplet-based microfluidic device applied to multiparameter analysis of single microbes and microbial communities Leung, K.; Zahn, H.; Leaver, T. Proceedings of the National Academy of Sciences, Vol. 109, Issue 20 https://doi.org/10.1073/pnas.1106752109	journal	April 2012
Electrochemical Detection of Single Molecules Fan, F. -R. F.; Bard, A. J. Science, Vol. 267, Issue 5199 https://doi.org/10.1126/science.267.5199.871	journal	February 1995
Nanoscale Control and Manipulation of Molecular Transport in Chemical Analysis Bohn, Paul W. Annual Review of Analytical Chemistry, Vol. 2, Issue 1 https://doi.org/10.1146/annurev-anchem-060908-155130	journal	July 2009
Localized Surface Plasmon Resonance Spectroscopy and Sensing Willets, Katherine A.; Van Duyne, Richard P. Annual Review of Physical Chemistry, Vol. 58, Issue 1 https://doi.org/10.1146/annurev.physchem.58.032806.104607	journal	May 2007
Single-Molecule Enzyme Dynamics of Monomeric Sarcosine Oxidase in a Gold-Based Zero-Mode Waveguide Zhao, Jing; Branagan, Sean P.; Bohn, Paul W. Applied Spectroscopy, Vol. 66, Issue 2 https://doi.org/10.1366/11-06464	journal	February 2012
Publication/Subscription/Member Data Dryden, Hugh L. Journal of the Aeronautical Sciences, Vol. 20, Issue 9, p. 656-656 https://doi.org/10.2514/8.2789	journal	September 1953
The Antimicrobial Resistance Crisis: Causes, Consequences, and Management Michael, Carolyn Anne; Dominey-Howes, Dale; Labbate, Maurizio Frontiers in Public Health, Vol. 2 https://doi.org/10.3389/fpubh.2014.00145	journal	September 2014
A Novel Glucose Biosensor Based on Hierarchically Porous Block Copolymer Film Guo, Teng; Gao, Jiefeng; Qin, Xiang Polymers, Vol. 10, Issue 7 https://doi.org/10.3390/polym10070723	journal	July 2018
Directed Self-Assembly of Block Copolymers for the Fabrication of Functional Devices Pinto-Gómez, Christian; Pérez-Murano, Francesc; Bausells, Joan Polymers, Vol. 12, Issue 10 https://doi.org/10.3390/polym12102432	journal	October 2020
Block Copolymers: Synthesis, Self-Assembly, and Applications Feng, Hongbo; Lu, Xinyi; Wang, Weiyu Polymers, Vol. 9, Issue 12 https://doi.org/10.3390/polym9100494	journal	October 2017

Similar Records

Single Entity Electrochemistry in Nanopore Electrode Arrays: Ion Transport Meets Electron Transfer in Confined Geometries

Journal Article · Mon Jan 27 23:00:00 EST 2020 · Accounts of Chemical Research · OSTI ID:1762420

Asymmetric Nafion-Coated Nanopore Electrode Arrays as Redox-Cycling-Based Electrochemical Diodes

Journal Article · Mon Aug 06 00:00:00 EDT 2018 · ACS Nano · OSTI ID:1494075

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Nanochannels
Nanoparticle
Optical waveguides
Polymers
Spectroelectrochemistry

Multifunctional nanopore electrode array method for characterizing and manipulating single entities in attoliter-volume enclosures

Citation Formats

References (89)

Similar Records

Related Subjects