Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase

Englund, Elias; Schmidt, Matthias; Nava, Alberto A.; Lechner, Anna; Deng, Kai; Jocic, Renee; Lin, Yingxin; Roberts, Jacob; Benites, Veronica T.; Kakumanu, Ramu; Gin, Jennifer W.; Chen, Yan; Liu, Yuzhong; Petzold, Christopher J.; Baidoo, Edward E. K.; Northen, Trent R.; Adams, Paul D.; Katz, Leonard; Yuzawa, Satoshi; Keasling, Jay D.

doi:10.1021/jacs.2c11027

Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase

Journal Article · Fri Apr 14 00:00:00 EDT 2023 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.2c11027· OSTI ID:1970085

^[1]; Schmidt, Matthias ^[2]; ^[3]; Lechner, Anna ^[4]; Deng, Kai ^[5]; Jocic, Renee ^[6]; Lin, Yingxin ^[7]; Roberts, Jacob ^[8]; Benites, Veronica T. ^[6]; Kakumanu, Ramu ^[6]; Gin, Jennifer W. ^[6]; Chen, Yan ^[6]; Liu, Yuzhong ^[4]; ^[6]; Baidoo, Edward E. K. ^[6]; ^[9]; Adams, Paul D. ^[10]; Katz, Leonard ^[11]; ^[12]; ^[13]

Joint BioEnergy Institute, Emeryville, California 94608, United States, Science for Life Laboratory, KTH - Royal Institute of Technology, 17165 Stockholm, Sweden
Joint BioEnergy Institute, Emeryville, California 94608, United States, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Institute of Applied Microbiology, Aachen Biology and Biotechnology, RWTH Aachen University, 52074 Aachen, Germany
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States, Department of Bioengineering, University of California, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Department of Biomaterials and Biomanufacturing, Sandia National Laboratory, Livermore, California 94550, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Department of Bioengineering, University of California, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Department of Bioengineering, University of California, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, QB3 Institute, University of California, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa 252-0882, Japan, Institute of Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0017, Japan
Joint BioEnergy Institute; Emeryville; California 94608; United States; Biological Systems and Engineering Division; Lawrence Berkeley National Laboratory; Berkeley; California 94720; United States; Department of Chemical and Biomolecular Engineering; University of California; Berkeley; California 94720; United States; Department of Bioengineering; University of California; Berkeley; California 94720; United States; QB3 Institute; University of California; Berkeley; California 94720; United States

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Research Organization:: Univ. of California, Berkeley, CA (United States)

Sponsoring Organization:: Formas Mobility; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1970085

Alternate ID(s):: OSTI ID: 1971468

Journal Information:: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 16 Vol. 145; ISSN 0002-7863

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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