Production of Radioisotopes of Scandium for Imaging and Therapy (Final Report)
- Univ. of Alabama, Birmingham, AL (United States)
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Argonne National Laboratory (ANL), Argonne, IL (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
The theranostic approach is a powerful technique that enables scientists and physicians to diagnose and treat diseases using the same targeting moiety labeled with radionuclides for imaging and therapy. A challenge behind synthesizing and evaluating these theranostic radiopharmaceuticals lies in the production of suitable radionuclides. This study aimed to investigate the production of high radionuclidic purity 43Sc from enriched [46Ti]TiO2 for Positron Emission Tomography (PET) and 47Sc from enriched [50Ti]TiO2 for targeted radiotherapy, as well as establish a target recycling technique for continued production of these radionuclides. Methods: Targets were prepared with 100 mg of either enriched [46Ti]TiO2 or [50Ti]TiO2, pressed into pellets, and placed into Ta target holders with a 0.127 mm natTi cover foil. The 46Ti targets were bombarded with 18 MeV protons at 20 µA for 1.5 h, while 50Ti targets were bombarded with 24 MeV protons at 20 µA for 4 or 8 h. The radioscandium nuclides were purified using branched N, N, N’, N’-tetra-2-ethylhexyldiglycolamide (DGA) resin. The titanium targets were recycled by precipitating the dissolved Ti collected from the column effluent and wash streams, pH adjustment, vacuum filtration, and then drying the solid at 250 °C prior to reforming the target for the subsequent bombardment. The apparent molar activity of the isolated radioscandiums was analyzed by titration with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). The relative imaging performance of 18F, 43Sc, and 68Ga were analyzed with PET images acquired with 30-min static scans. Results: The average radioscandium recovery for 43Sc was 91.7 ± 7.4 %, with a radionuclidic purity of 98.8 %. The average recovery of 47Sc was 89.9 ± 3.9 %, with a radionuclidic purity of 90.8%. The average recovery of enriched TiO2 was 96 ± 4.0 %. The highest apparent molar activity for [43Sc]Sc-DOTA was 23.2 GBq/µmol and 3.39 GBq/µmol for [47Sc]Sc-DOTA. The order of PET resolution from highest to lowest was 18F > 43Sc > 68Ga. Conclusions: This work demonstrates the feasibility of using enriched recycled [46Ti]TiO2 and [50Ti]TiO2 targets for the production of the 43Sc and 47Sc theranostic isotope pair in high purity.
- Research Organization:
- Univ. of Alabama, Birmingham, AL (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP)
- DOE Contract Number:
- SC0020197
- OSTI ID:
- 1967920
- Report Number(s):
- 1; TRN: US2406089
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets
Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics