Differentiating Vaccine-Related Fowl Cholera from Naturally Occurring Disease

Hutcheson, Anna R.; Thompson, Kasey; Maurer, John J.; Ferguson, Naola; Grogan, Karen; Roney, Stephen; Seahorn, Harmony; Lobsinger, Chris; Lee, Margie D.

doi:10.1637/aviandiseases-d-20-00024

Differentiating Vaccine-Related Fowl Cholera from Naturally Occurring Disease

Journal Article · Mon May 18 00:00:00 EDT 2020 · Avian Diseases

DOI:https://doi.org/10.1637/aviandiseases-d-20-00024· OSTI ID:1963914

Hutcheson, Anna R. ^[1]; Thompson, Kasey ^[2]; Maurer, John J. ^[3]; Ferguson, Naola ^[4]; Grogan, Karen ^[4]; Roney, Stephen ^[5]; Seahorn, Harmony ^[4]; Lobsinger, Chris ^[4]; Lee, Margie D. ^[3]

Univ. of Georgia, Athens, GA (United States); Atlanta Veterans Affairs Medical Center, Decatur, GA (United States); Virginia Tech
Univ. of Georgia, Athens, GA (United States); USDA Food Safety Inspection Service, Athens, GA (United States)
Univ. of Georgia, Athens, GA (United States); Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
Univ. of Georgia, Athens, GA (United States)
Univ. of Georgia, Athens, GA (United States); CSR Poultry Health Consulting, Midland City, AL (United States)

Vaccine-related fowl cholera must be considered when flock mortality increases after use of a live Pasteurella multocida vaccine product. All registered live vaccines serotype as Heddleston 3,4; however, in some regions this is also the most common serotype of outbreak isolates in broiler breeders and turkeys. Therefore, serotyping may not be useful for diagnosing vaccine-related fowl cholera. This project sought to apply a vaccine-specific test to differentiate vaccine-related disease from naturally occurring outbreaks. Results indicate that vaccine strains were commonly isolated from broiler breeders exhibiting signs of fowl cholera post vaccination, but some of these isolates exhibited only serotype 4 antigenicity. The isolates’ lipopolysaccharides, the target antigen for serotyping, contained compositional changes that may explain the varying serotype results and virulence of the commercial preparations. Furthermore, these results suggest that vaccine-related disease may be common in broiler breeders, and live commercial vaccine preparations need to be assessed for serotype and titer prior to use in order to reduce vaccine-related fowl cholera.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Georgia, Athens, GA (United States). Complex Carbohydrate Research Center

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division

Grant/Contract Number:: SC0015662

OSTI ID:: 1963914

Alternate ID(s):: OSTI ID: 1852019

Journal Information:: Avian Diseases, Journal Name: Avian Diseases Journal Issue: 4 Vol. 64; ISSN 0005-2086

Publisher:: American Association of Avian Pathologists - Allen PressCopyright Statement

Country of Publication:: United States

Language:: English

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