The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study

Liu, Yuanxia; Chen, Hongmei; Zhang, Mengtian; Zhu, Gangjiao; Yang, Yan; Li, Yuanyuan; Lu, Wei; Zhang, Hongling

doi:10.3389/fpubh.2023.1145113

The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study

Journal Article · Mon Mar 27 00:00:00 EDT 2023 · Frontiers in Public Health

DOI:https://doi.org/10.3389/fpubh.2023.1145113· OSTI ID:1963361

Liu, Yuanxia; Chen, Hongmei; Zhang, Mengtian; Zhu, Gangjiao; Yang, Yan; Li, Yuanyuan; Lu, Wei; Zhang, Hongling

Background

Selenium (Se) is an essential trace element for the human body. Serum Se and urinary Se are also biomarkers to assess Se exposure status. However, studies focusing on the association between urinary Se and the risk of gestational diabetes mellitus (GDM) are rare.

Objective

To investigate the association between urinary Se and the risk of GDM.

Methods

A nested case–control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children’s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed.

Results

Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interaction with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses.

Discussion

Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 1963361

Journal Information:: Frontiers in Public Health, Journal Name: Frontiers in Public Health Vol. 11; ISSN 2296-2565

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

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